Twenty One Grams

Twenty One Grams

Year: 2022

Runtime: 133 mins

Language: Malayalam

Director: Bibin Krishna

Echo Score: 78
CrimeDramaThriller

A police officer, Nanda Kishore, grappling with a personal tragedy, finds himself investigating a complex murder case. As he delves deeper into the investigation, he uncovers surprising connections that suggest the case may be intertwined with his own life and loss. The mounting evidence forces him to confront a disturbing reality and question everything he thought he knew.

Warning: spoilers below!

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Timeline & Setting – Twenty One Grams (2022)

Explore the full timeline and setting of Twenty One Grams (2022). Follow every major event in chronological order and see how the environment shapes the story, characters, and dramatic tension.

Time period

Location

Tamil Nadu, India

A modern Indian city in Tamil Nadu featuring a major multispeciality hospital and a bustling business district. The city hosts high-profile parties at luxury hotels, where powerful players mingle. The atmosphere is tense, with murders, cover-ups, and investigations threading through its streets.

🌆 Urban city 🏥 Hospital hub

Last Updated: October 01, 2025 at 09:50

Main Characters – Twenty One Grams (2022)

Meet the key characters of Twenty One Grams (2022), with detailed profiles, motivations, and roles in the plot. Understand their emotional journeys and what they reveal about the film’s deeper themes.

Nandan (Anoop Menon)

Senior deputy superintendent of the Police Crime Branch. A grieving father after his daughter's death, he pursues the truth with methodical scrutiny, balancing empathy with determination. His skepticism of official narratives drives him to uncover a systemic conspiracy behind Anjali's murder and the hospital's abuses.

🔎 Investigative 😢 Grieving 🧠 Analytical

Jimmy Cheriyan (Aji John)

A powerful, shrewd entrepreneur whose network spans hospitals and high-profile ventures. He wields influence to shield himself and manipulate others, making him a central figure in the conspiracy even as he remains under suspicion rather than the sole killer.

🕴️ Business 🗝️ Power 🧪 Corruption

Anjali (Manasa Radhakrishnan)

A biomedical engineer whose life is marked by ambition and danger. She records evidence of unauthorised drug trials and attempts to expose the truth, even as threats close in on her. Her murder and the subsequent revelation of her video message spur Nandan to press for justice.

🔬 Biomedical 🗝️ Evidence ⚖️ Truth

Tony (Tipper Tony)

A trusted enforcer tied to the criminal network around the hospital. He uses intimidation and a fake SIM to conceal his role in the murders; his involvement leaves behind key clues, although he is eventually replaced in the scheme.

🗡️ Violent 🕶️ Shadowy 🗝️ Accomplice

John Samuel

Owner of the multispeciality hospital, a powerful figure behind the drug trials and murders. He evades immediate accountability, becoming a central target once the evidence surfaces and the conspiracy unfolds.

🧪 Pharmaceutical 🔎 Manipulative ⚖️ Lawful Power

Dr. Alex Koshy (Renji Panicker)

A doctor at the hospital connected to the drug trial schemes. His role blurs the line between medical ethics and institutional pressure, prompting questions about responsibility and complicity.

🧬 Doctor 🧠 Investigator ⚖️ Ethics

Gauri (Leona Lishoy)

Nandan's wife, grieving after their daughter's death. Her emotional resilience anchors the investigation and highlights the personal costs of crime in a family’s life.

💔 Wife 🧠 Grief ❤️ Family

Vinay

Gauri's brother who wrestles with grief and antidepressant use. He is entangled in the case through his connections to the hospital and the drug trials, complicating the investigation until the truth emerges.

💊 Medication 🧠 Family 🕯️ Strain

Nikhil

A staff member and trusted assistant to John Samuel. His actions become pivotal evidence, and his death marks a turning point in the investigation.

🔎 Witness 🕵️ Investigation ⚠️ Danger

Shihab Muhammed (Shihab)

An investigative journalist who tried to expose unauthorised drug trials and whose death catalyzes the pursuit of evidence. His work highlights the peril faced by reporters uncovering corruption.

🗞️ Journalist 🔎 Investigator ⚖️ Risk

Last Updated: October 01, 2025 at 09:50

Major Themes – Twenty One Grams (2022)

Explore the central themes of Twenty One Grams (2022), from psychological, social, and emotional dimensions to philosophical messages. Understand what the film is really saying beneath the surface.

🕵️ Justice Pursuit

The investigation drives the plot as Nandan traces a web of killings, forged communications, and powerful suspects. Evidence disappears and suspects manipulate narratives, testing the integrity of police work. The theme centers on the pursuit of truth in a city where power can obscure crime.

💔 Grief & Secrets

Nandan's personal tragedy over his daughter's death drives his determination, while Anjali's hidden evidence threatens to expose dangerous practices. The case intertwines family loss with a broader conspiracy, showing how grief can fuel a relentless hunt for justice. Personal pain and professional duty collide as secrets emerge.

💰 Power Corruption

The case exposes how hospital leadership, business magnates, and unauthorised drug trials intersect to protect profits. Corporate influence tamps down evidence, enabling manipulation and cover-ups. The pursuit of money and prestige clashes with ethical standards and public safety.

Last Updated: October 01, 2025 at 09:50

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Twenty One Grams Summary

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Twenty One Grams Summary

Twenty One Grams Timeline

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Twenty One Grams Timeline

Twenty One Grams Spoiler-Free Summary

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Twenty One Grams Spoiler-Free Summary

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