A bleeding woman named Jessica Murdock [Hayley Erin] escapes from a containment facility and flees across the Pacific Northwest, hoping to reach the Canadian border. Jessica kills a guard [Colton Ruscheinsky] during her escape and believes that she is being pursued for murder, setting off a tense pursuit through rural roads and small towns as she tries to stay ahead of her pursuers.
Elsa Gray [Sonya Walger], a fixer who is quietly battling an ALS diagnosis, begins to pursue Jessica with a sense of urgency and personal stake. She follows a trail of clues that lead her to believe Jessica is infected with a dangerous strain, and her pursuit unfolds with a blend of professional determination and underlying conflict. Along the way, Jessica meets several kind strangers who misread her situation, assuming she is fleeing from domestic violence. These acts of kindness include an elderly couple who work on a farm and a warm, protective bartender named Molly [Ayanna Berkshire], who offers shelter and a listening ear to a woman who seems desperate and frightened.
Elsa is initially told that she is working for the government and that Jessica is infected with a strain of Ebola virus, a story that drives her actions with a particular sense of urgency and secrecy. Her investigation leads her to the home of Janie [Betty Moyer] and Frank [Blaine Palmer], the farmers who welcomed Jessica earlier in her flight. The devastating sight of Janie and Frank having become zombies forces Elsa to take a drastic action and shoot them, a moment that shatters her perception of whoJulia and who is protecting whom.
As the truth unfolds, Elsa learns that she is actually working for a pharmaceutical company trying to protect its reputation, complicating her sense of loyalty and duty. Jessica is not carrying Ebola, but rather an unknown infectious agent that may have infected her in a troubling way—she was infected by a dog that escaped from the containment facility. The gravity of the situation deepens as Jessica witnesses Molly—the bartender she once met—becoming a zombie, and she realizes with horror that she herself is contagious.
In a tense confrontation, Elsa and Jessica face one another, with Jessica insisting that she will never return to the facility. As infection signs grow, Elsa is forced to make a painful decision and ends Jessica’s life. Elsa returns home to a life that will demand new adaptations; a caretaker helps her plan to modify her home to be ALS-accessible, creating a space where she can live more comfortably with her condition. The caretaker’s unexpected cough at the end suggests that the threat of infection may not be over, hinting at a new worry that Elsa herself could be at risk.