In Los Angeles, undercover officers arrive at a motel where those inside, including Jacqueline Wilson, are trafficking illegal drugs. During the escape, an officer and one of Jacqueline's accomplices are shot, while two of them escape. Jacqueline is arrested and sentenced to 40 years inside a women's correctional prison for possession of illegal drugs and attempted murder.
Upon her arrival, Jacqueline is strip searched and dines with her fellow inmates inside the cafeteria. The next morning, the inmates are transferred to Connorville Correctional Institute for Women, under the control of Superintendent McQueen. There, they are entertained to a drag show but McQueen leaves in disgust. The next morning, McQueen reprimands Belle and Pandora, two of the inmates who organized the drag show. McQueen punishes Pandora to solitary confinement after discovering a photograph of her boyfriend inside her cell.
While showering, Jacqueline gets into an altercation with Maggie, to which McQueen threatens her with behavioral therapy. Back in her cell, Belle tells her criminal history to Jacqueline. During the next morning, Belle crawls through an air vent and steals food from the staff lounge. She gives the food to Pandora, who is still under confinement. Meanwhile, inside the kitchen, Maggie assaults one of the officers and steals her handgun. She then sets a fire and attempts to free herself, but she is prevented. Although Jacqueline tried to save the officer, McQueen sends her to the behavioral clinic, where she is given shock therapy.
The next morning, Belle attempts to steal food again, but is caught by a kitchen matron. Belle pushes her against the refrigerator, and the matron dies. She is then apprehended and taken to the clinic. Outside, the inmates are picking apples where Maggie fakes a medical accident. She assaults an officer and steals a prison transport truck where Jacqueline hitches in. They take the truck to an auto repair shop, where the mechanic helps the women to escape after an officer spots the truck.
Along the road, Maggie and Jacqueline steal a couple's car and arrive at a brothel. There, Maggie reunites with her friend Crazy Alice. Jacqueline calls her friend Sparky, asking him to create fake IDs. One of Alice's sex clients turns out to be an undercover officer, who attempts to arrest her and Maggie under suspicions of soliciting a prostitute. Both women immobilize the officer and escape.
Back at the prison, Lavelle, one of the inmates who attempted to escape, is relieved from further therapy based on good behavior, and is given a job at the clinic. There, Doctor Randolph makes Belle, who is under sedation, sign a medical form allowing him to perform psychological surgery if she wants parole. Randolph then sexually assaults Belle, which is witnessed by Lavelle. On the lam, Jacqueline and Maggie attempt a bank robbery, but a gang of male robbers have beaten them to it. Officers arrive outside the bank, and the women escape. Jacqueline decides to return to the prison to free the other inmates. Maggie initially resist, but changes her mind. They hijack a transport truck and are driven inside the compound.
Meanwhile, Lavelle alerts Pandora about Randolph's unethical behavior. Pandora injures herself and is taken to the clinic, where she holds Randolph at knifepoint. Jacqueline arrives, and holds Randolph and McQueen at gunpoint. Jacqueline and Pandora subdue them, where they, along with Belle and Lavelle, attempt to escape. Pinter, who is McQueen's assistant warden, sounds an alarm which alerts the prison officers outside. The women and the officers engage in a shootout, in which McQueen and Randolph are shot inside. The women escape into Maggie's convertible and drive off.
