Isolation

Isolation

Year: 2005

Runtime: 95 mins

Language: English

Director: Billy O'Brien

HorrorScience FictionHorror the undead and monster classicsSci-fi horror creatures and aliensGory gruesome and slasher horror

It didn’t want to be born. Now it doesn’t want to die. On a remote Irish farm, five people become unwilling participants in an experiment that goes nightmarishly wrong.

Warning: spoilers below!

Haven’t seen Isolation yet? This summary contains major spoilers. Bookmark the page, watch the movie, and come back for the full breakdown. If you're ready, scroll on and relive the story!

Timeline – Isolation (2005)

Trace every key event in Isolation (2005) with our detailed, chronological timeline. Perfect for unpacking nonlinear stories, spotting hidden connections, and understanding how each scene builds toward the film’s climax. Whether you're revisiting or decoding for the first time, this timeline gives you the full picture.

1

Orla is bitten by the unborn calf

Orla palpates a cow and is seemingly bitten by the unborn calf. She informs John of the strange bite, but he dismisses her concerns and urges secrecy about the experiment. The incident hints at a dangerous, unknown parasite at work on the farm.

Night 1 Farm in rural Ireland
2

Dan orders Jamie and Mary off the farm

Dan confronts Traveller Jamie and his girlfriend Mary and tells them they must leave by morning due to the secret experiments. He warns them to keep quiet and maintain distance from the farm. The tension on the farm rises as outsiders become involved.

Next morning Dan's farm
3

Calf birth and Dan is bitten

That same night one cow goes into difficult labour. Dan enlists Jamie's help to birth the calf, and together they manage it. The calf bites Dan during the delivery, earning his temporary gratitude, and he invites Jamie and Mary to stay.

That night Dan's farm barn
4

Orla finds fanged calf and six deformed foetuses

Next day Orla inspects the calf and discovers it has fangs. When she decides to terminate the calf, its mother attacks in defense and Orla is forced to kill them both. A necropsy reveals six malformed foetuses with skeletons growing outside their bodies, suggesting an unusual and dangerous infection.

Next day Farm and necropsy lab
5

Jamie is bitten in the barn water

Next morning Jamie notices strange wounds on a cow, and something bites him as he passes through shallow water in the barn. The farm's mood darkens as illness and fear spread. The first inklings that the infection may be contagious reach the couple.

Next morning Farm barn
6

Orla disappears; police visit the farm

A police officer arrives at the farm and informs Dan that Orla is missing. The absence adds to the growing sense of danger and the authorities' concern grows.

That night Dan's farm
7

John discovers rapid cell growth in foetuses

John returns to the on-site lab to check the experiments and learns about the malformed foetuses. He discovers their cells are multiplying extremely quickly and realizes the threat could extend to humans.

Late night Farm lab
8

A creature appears in the caravan

Inside the Traveller caravan, Mary notices unusual behavior from Jamie as they are together. They are awakened by a creature crawling in their bed, and it quickly escapes.

That night Traveller caravan near farm
9

Farm quarantined to stop the outbreak

John informs that the entire farm must be quarantined to prevent the creature from infecting other cows and sparking a pandemic. The quarantining order heightens tension as workers scramble to seal the farm and monitor livestock.

Next day Farm
10

Creature hides in murky floodwater; Orla's body found

They begin searching for the creature but find that it is hiding in the murky water flooding the farm. Dan uses his tractor to flush it out, but instead discovers Orla's body in the water.

Evening Farm floodwater area
11

John finds human cells in Orla's wound

John takes Orla's body to the lab and finds foreign material inside a wound on her abdomen. The material shows extreme cell growth and also contains human cells, leading him to realize that humans may be susceptible to the infection.

Following night Lab
12

Jamie infected; John kills him

Jamie realizes he is infected and tries to escape, but John kills him. John explains that he has killed almost every cow on the farm in his search for the creature.

Soon after Farm
13

Final calf escapes; John is killed by creature; Dan survives

They reach the barn where the final cow is kept, but the calf has already been born and escaped. John is attacked and killed by the creature while chasing Mary, and Dan survives the earlier confrontation. They continue to search for the monster.

Final confrontation night Farm barn
14

Mary defeats the creature; Dan dies; Mary leaves farm

Mary finds the calf as new creatures rupture from its body. Dan creates a diversion by making noise to lure the creature away, allowing Mary to injure it with boiling water and finish it off. Dan dies from his injuries, while Mary leaves the farm.

Night of final battle Farm
15

Four months later in Birmingham; creature seen in foetus

Four months later in Birmingham, England, Mary is pregnant and the baby is deemed healthy. In an ultrasound, a creature-like shape is briefly seen inside the fetus, hinting that the threat may not be over.

Four months later Birmingham, England

Last Updated: October 09, 2025 at 15:13

Mobile App Preview

Coming soon on iOS and Android

The Plot Explained Mobile App

From blockbusters to hidden gems — dive into movie stories anytime, anywhere. Save your favorites, discover plots faster, and never miss a twist again.

Sign up to be the first to know when we launch. Your email stays private — always.

Unlock the Full Story of Isolation

Don't stop at just watching — explore Isolation in full detail. From the complete plot summary and scene-by-scene timeline to character breakdowns, thematic analysis, and a deep dive into the ending — every page helps you truly understand what Isolation is all about. Plus, discover what's next after the movie.

Isolation Summary

Read a complete plot summary of Isolation, including all key story points, character arcs, and turning points. This in-depth recap is ideal for understanding the narrative structure or reviewing what happened in the movie.

Isolation Summary

Characters, Settings & Themes in Isolation

Discover the characters, locations, and core themes that shape Isolation. Get insights into symbolic elements, setting significance, and deeper narrative meaning — ideal for thematic analysis and movie breakdowns.

Characters, Settings & Themes in Isolation

Isolation Spoiler-Free Summary

Get a quick, spoiler-free overview of Isolation that covers the main plot points and key details without revealing any major twists or spoilers. Perfect for those who want to know what to expect before diving in.

Isolation Spoiler-Free Summary

More About Isolation

Visit What's After the Movie to explore more about Isolation: box office results, cast and crew info, production details, post-credit scenes, and external links — all in one place for movie fans and researchers.

More About Isolation

Similar Movies to Isolation

Discover movies like Isolation that share similar genres, themes, and storytelling elements. Whether you’re drawn to the atmosphere, character arcs, or plot structure, these curated recommendations will help you explore more films you’ll love.