Practically from the time she was an infant, Rose Cooper has been shadowing her father, a well-respected police officer in San Antonio, Texas, during his patrols in the police cruiser. As she grew up, he began allowing her to accompany him on certain arrests, which sparked her ambition to forge a career in law enforcement. Though as an adult, her intense dedication to her job has interfered with her personal life. On a date gone wrong, she frightens her suitor by defensively brandishing her gun. In a twist of fate, she chases him down merely to return his wallet.
At the precinct, Cooper is called to meet Detective Jackson (portrayed by Richard T. Jones), while Captain Emmett (John Carroll Lynch) briefs them on a vital task. They have to provide protection for cartel informant Felipe Riva (Vincent Laresca) and his wife, Daniella, due to Felipe's decision to testify against the notorious cartel leader Vicente Cortez (Joaquin Cosio) in Dallas. This mission represents Cooper's opportunity to step back into the field after a recent incident involving the mayor's son, which controversially resulted in a comical tasing and unfortunate consequences — her mishaps have become the stuff of jokes.
Upon reaching the Riva residence, they discover an agitated Daniella, who blames her husband for putting them in danger. Suddenly, shots ring out as two masked assailants invade the home, killing both Jackson and Felipe. In a desperate bid, Cooper rushes to the garage, where she finds Daniella hiding in a car, and together they escape the scene. Breaking the harrowing news of Felipe's death to her, Daniella's reaction is one of pure anguish. When Daniella attempts to seek help with her phone, Cooper insists that she throw it away for their safety. In an impulsive act, Cooper handcuffs herself to Daniella to keep her close just as chaos ensues — a truck collides with the car, scattering a trove of cocaine everywhere. In this wild turn of events, Cooper finds herself inadvertently consuming the drugs and hitches a ride from the truck driver to a nearby store for new clothes.
As news spreads that Cooper is now a fugitive, having taken Daniella with her, the situation escalates when they encounter officers Dixon (Michael Mosley) and Hauser (Matthew Del Negro), who are misidentified as the shooters due to Hauser's longhorn tattoo. The ladies concoct a story about a medical situation to escape, sneaking out a bathroom window only to run into Dixon. In a moment of bravery, Cooper fires her gun to create a diversion, giving them a chance to flee. They find refuge in the back of a wagon, where curiosity leads Cooper to inquire about the content of Daniella's luggage. Daniella reveals it holds a stash of diamond-encrusted shoes given to her by her late brother, a poignant reminder of her past.
The tension mounts as they encounter Red (Jim Gaffigan), a man with a gun, leading to a chaotic moment where Daniella pretends to be Cooper's romantic partner in a desperate bid to gain his sympathy, which backfires in dramatic fashion. As the trio journey further, Cooper and Daniella start to bond, discussing their struggles in love and life. A random encounter with Randy (Robert Kazinsky), a felon with a troubled history, brings both comic relief and the promise of assistance — they strike a deal, and a budding chemistry ignites between Cooper and Randy, much to Daniella's amusement.
Their escapade takes an unexpected turn when they find temporary lodging. In a series of tangled events with Randy, Cooper finds herself in flirtation territory and ultimately drawn into a brief moment of intimacy, only to return to a shocking discovery: Daniella, now wielding Cooper's gun, confronts her about doubts regarding her credibility as a witness. The stakes soar higher when Daniella learns that the shoes she carries are worth a staggering $4 million, linking back to Felipe's money-laundering scheme. With the crooked cops hot on their trail, a showdown erupts during their escape, revealing the urgency of their mission.
As the duo makes their way onto a tour bus, their flight from danger culminates in a reckless chase, leading them to a programmed quinceañera event where Cooper devises a plan to entrap Cortez. The climax draws near when she hopes to gather evidence amidst an emotional confrontation between Daniella and Cortez, revealing further betrayal and backlash. In a critical moment, Cooper steps in as tensions spike, preventing a calamity that could cost Daniella her closure.
In the aftermath, the dust begins to settle. With newfound respect from the police, Cooper rejoices in her triumph over Dixon and Hauser, reflecting on her unyielding spirit for justice. As she picks up Daniella from prison after serving her sentence for obstruction, she embraces the strength of their friendship, gifting her the diamond-studded shoes that once symbolized a life of crime. Together, they walk away arm in arm as the laughter of camaraderie resonates, hinting at brighter days ahead. The film closes with lighthearted bloopers, leaving the audience with chuckles and memories of a wild adventure.
