As the refined yet troubled actress Lauren Ames (Shelley Long) embarks on a transformative journey guided by the esteemed theatre professor Stanislav Korzenowski (Robert Prosky), her path takes an unexpected turn when she crosses paths with the boisterous and outspoken Sandy Brozinsky (Bette Midler). The initial interaction between these two actresses is marked by underlying tensions, as their mutual disdain simmers just beneath the surface. Unbeknownst to them, they find themselves entangled in a complex web of relationships with Michael Santers (Peter Coyote), a charismatic individual whose life takes a devastating twist following an explosive incident at a local store that leaves much speculation about his fate.
In the wake of this tragic turn, both Lauren and Sandy grapple with the shock of their shared love interest's apparent demise. However, their grief quickly transforms into a burning curiosity as they uncover a staggering revelation: Michael may have orchestrated his own death. This discovery compels the two actresses to form a tenuous alliance, united by a fierce determination to unravel the mystery surrounding Michael's sudden disappearance. Their quest catapults them on a perilous journey across the country, fraught with danger as they encounter relentless CIA agents, cunning Russian assassins, and a series of cryptic clues.
As their investigation deepens, Lauren and Sandy find themselves pursued by merciless operatives, each with their ominous agendas aimed at recapturing Michael. The tension escalates dramatically when they pinpoint his location, only to learn that he operates as a double agent entangled in the machinations of both the CIA and the KGB. With the potential possession of a lethal toxin capable of catastrophic destruction looming large, both organizations become embroiled in chaos.
The thrilling chase intensifies when Lauren is taken hostage by Michael's rogue associates, who demand a trade with the CIA for the toxin. Seizing a moment of opportunity when the deal deteriorates, Lauren deftly escapes with both the stolen cash and the potent toxin, triggering a frantic pursuit by Michael and his crew. As they are cornered amidst a breathtaking landscape of rugged mountaintops, Lauren relies on her former ballet training to elude capture. Ultimately, she executes a daring grand jeté, sending Michael tumbling to what seems to be his demise.
In the aftermath of their tumultuous escapades, Lauren and Sandy emerge with an unbreakable bond, strengthened through the challenges they have overcome together. Looking ahead, they commit to once again gracing the stage, this time as co-stars in a production of Hamlet, with Lauren stepping into the titular role and Sandy portraying Ophelia.
