Ordering food at a taco stand late at night, Link Brown, played by Antonio Fargas, finds himself under the watchful eyes of two thugs, Eddie and Bunyon, who have been tailing him. Just then, two police officers pull up to place their food orders. Feeling the tension, Link hurriedly calls his sister, Foxy Brown (Pam Grier), from a nearby payphone, alerting her that danger is imminent once the officers leave. Prompted by his distress, Foxy springs into action—she swiftly changes into her clothes and stashes a gun in her brassiere before racing to his side.
As Link attempts to engage the officers in conversation, they drive off, leaving him vulnerable. Just as Eddie and Bunyon close in, Foxy heroically swoops in, hitting the thugs with her car, allowing Link to jump through the sunroof and escape. Back at her home, Foxy presses Link for answers, and he admits he owes $20,000 to a loan shark, which he lost in a betting mishap. He argues that his trouble is minor compared to her missing boyfriend's dubious activities as a police informer. Despite her protective instincts, Foxy allows Link to stay with her, hoping to keep him from further trouble.
Meanwhile, in Katherine Wall's (Kathryn Loder) office, Steve Elias (Peter Brown) reprimands Eddie and Bunyon for failing to capture Link. At the hospital, Foxy visits her boyfriend, Dalton Ford (Terry Carter), as he undergoes surgery to alter his appearance to take on a new identity: "Michael Anderson." After his recovery, they stroll through the streets where they encounter Foxy’s friend, Oscar (Bob Minor), who describes his vigilante efforts to rid the neighborhood of drug dealers.
Tensions mount when Link worries for his girlfriend Deb (Sally Ann Stroud) after learning Elias's thugs have threatened her. After an intense confrontation, Foxy realizes her brother could jeopardize Michael's safety, leading her to pursue answers through dubious means.
Disguised as "Misty Cotton," Foxy infiltrates Katherine Wall's modeling agency, intending to uncover the inner workings of the drug syndicate while keeping a close eye on the precarious situation with Judge Fenton (Harry Holcombe). Foxy faces danger as she gets entangled with Claudia (Juanita Brown), a fellow escort forced to navigate the dangers of their criminal dealings. The stakes rise when Elias learns of Foxy's threat and orders men to capture her.
After surviving a brutal attack, Foxy breaks free from her captors, using sheer determination and cleverness to arm herself with makeshift weapons and ultimately setting fire to her prison. In response to the havoc she wreaks, Miss Wall orders the hit on Foxy, resulting in a heartbreaking murder of Link and Deb. Devastated and furious, Foxy turns to the neighborhood committee for support in her quest for revenge against the drug lords who have wronged her.
As the chaos unfurls, Foxy cleverly seduces Elias's pilot, Hays (Sid Haig), gaining access to their hideout and unleashing her fury. Armed with a firearm concealed in her hair, she confronts Miss Wall in a show-stopping climax—determined not just to avenge her brother but to ensure that those who wronged her live with their consequences.
Her fight against the drug lords culminates in a final showdown, where she delivers a potent message of resilience and retribution, driving off into the night with Oscar by her side, leaving the remnants of the criminal empire she dismantled in her wake.
