A secluded village of Yetis thrives atop a Himalayan mountain, far removed from human eyes. At the heart of this society is Migo, a young yeti portrayed by Channing Tatum, who reveres the ancient laws enacted by the village's leader, Stonekeeper, played by Common. Migo's father, Dorgle (voiced by Danny DeVito), engages in a daily ritual of hitting a gong with his head to summon the sun. During one of these attempts, Migo becomes sidetracked by the enchanting Meechee, the daughter of the Stonekeeper, brought to life by Zendaya. This moment of distraction leads to a significant blunder where Migo misses the gong, resulting in his banishment for supposedly fabricating a tale about witnessing a legendary creature known as a "Smallfoot," or human.
In a surprising turn of events, Migo encounters Gwangi (voiced by LeBron James), Kolka (portrayed by Gina Rodriguez), and Fleem (played by Ely Henry), who introduce him to the Smallfoot Evidentiary Society (S.E.S.) led by Meechee. With determination, Meechee encourages Migo to venture below the clouds, despite the ominous warnings from the stones indicating peril. Hesitant yet resolute, Migo attempts this leap of faith but meets an unforeseen drop where he discovers land for the first time.
Meanwhile, in the bustling village of Simikot, Percy Patterson (voiced by James Corden), a filmmaker desperate to regain his lost credibility, concocts an outrageous plan involving his assistant Brenda (brought to life by Yara Shahidi). However, Brenda abandons him, leading Percy to the local pub where he unwittingly encounters Migo. Initially frightened, he finds himself in the midst of Migo's quest and, after an unexpected bear trap incident where he helps Migo, agrees to accompany him back up the mountain.
Upon their return, the village reacts with confusion to Percy's presence but gradually embraces him as he shares experiences from the human world. Yet, unease brews under the watchful eye of the Stonekeeper, who reveals the troubling truth: the Yetis were once victims of human aggression, forced into their high-altitude retreat. To safeguard their community, they created the stones as a barrier. Migo, torn between the truth and protecting his people, spins a tale that Percy is merely a wild yak.
However, a series of misadventures leads to a pivotal moment when Percy’s explosive video of Migo making its way into public circulation portrays Yetis as menacing creatures. Amid the chaos that ensues, the characters find themselves in a struggle against police misunderstanding and human prejudice. In a daring rescue, Migo and his friends must outsmart their adversaries, eventually leading to Percy and Brenda stepping up to advocate for the Yetis despite the danger.
As tensions peak and truths are unveiled, Migo, with newfound courage, urges his fellow Yetis to reach out to humans rather than hide away. In a heartwarming conclusion, the once-isolated Yetis reconnect with the world above the clouds, igniting a new era of understanding. In a whimsical post-credits scene, Percy realizes his own vulnerability when he discovers a missing tooth, hinting at all the adventures yet to come.
