Returning from a trip to Germany, Sean Floyd is excited to spend his spring break in the woods with his friends Jeremy Abelar and Donnie. Unbeknownst to Sean, Jeremy decides to invite his twin sister Becky—who recently went through a breakup with Chad—along with her friend Sarah, who happens to be Donnie's ex-girlfriend. The group encourages Sean to pursue Becky, the object of his affection, but tensions rise as they embark on their six-hour journey to the campsite.
Once they arrive, Sean tries to make a move on Becky but is quickly sidetracked by Donnie, who drags him to tease Jeremy. What follows is an unfortunate accident where Jeremy, brandishing a knife, accidentally injures himself in a rather shocking way. In a state of panic, Sean takes everyone's phones to find an area with service and attempts to call 9-1-1. Along the way, he mistakenly texts Chad from Becky's phone before losing all their phones during the chaos. A helicopter eventually arrives to assist, and Sean hands over a cooler containing what he believes is Jeremy's severed body part—a decision that sets off a whirlwind of misunderstandings.
After the commotion dies down, the group finds the real severed member in another cooler, leading to a hilarious realization that Sean has handed over the wrong item to the paramedics. At the hospital, the grim truth dawns on Jeremy as he faces the consequences of his friends' blunders. Meanwhile, the group’s adventures continue when they stumble upon a ranger station. When a startled Becky throws a cooler to scare off a rattlesnake, unexpected trouble ensues when the cooler’s contents spill out.
The comedic escapades go on as they chase after a drone belonging to an 11-year-old camping with his father, only to be mistaken for wrongdoers by the dad. In a scramble, the group manages to escape with the boat offered by the boy in exchange for the drone, leading them to a series of even crazier misadventures, including an encounter with a gas station clerk who cleans the severed member as an act of patriotism.
As the story unfolds, Donnie faces the repercussions of their antics, and when they finally return to the hospital, things get even more absurd. After numerous twists and turns, including a mix-up with another patient named Redneck Reginald, the saga culminates in a combination of heartfelt apologies and clever resolutions. Sean realizes the importance of being honest about feelings, leading him to mend fences with Becky, who soon agrees to start building a relationship with him.
As their chaotic journey comes to an end, Sean prepares to head back to Germany, and amidst celebrations and new relationships, Jeremy's wild story finds a comedic yet satisfying conclusion with the introduction of his girlfriend Kendall Jenners—a character that everyone assumes is a fabrication. The film ends with a memorable moment as Becky and Sean share an extraordinary kiss, encapsulating the growth and friendships that were forged amidst the chaos and absurdity of their unforgettable trip.
