In the lively and imaginative world of Shopwell's, a supermarket populated by anthropomorphic grocery items, the inhabitants perceive human shoppers as their deities, who whisk them away to the “Great Beyond” upon purchase. At the center of this bustling aisles is a spirited sausage named Frank and his charming hot dog bun girlfriend, Brenda. Frank dreams fervently of their union in the Great Beyond, a place where their relationship can finally blossom to its fullest potential.
However, a shocking twist unfurls when a disgruntled jar of Honey Mustard (Danny McBride) returns with tales of the Great Beyond being a mere illusion, compelling Frank to search for an old Native American bottle of liquor named Firewater. In a moment of chaos, Frank’s desperate leap from a shopping cart leads to a collision that sends several groceries tumbling to the floor, including Frank himself, impeding their chance at reaching paradise. Tensions escalate as characters like Kareem Abdul Lavash (David Krumholtz) and Douche (Nick Kroll), a malevolent feminine hygiene product, blame Frank for ruining their escape.
Amidst the turmoil, Frank and Brenda embark on a mission to find Firewater, but they soon face unforeseen challenges that test their bond. Separated during this chaotic search, Brenda encounters Teresa Del Taco, a vibrant female taco shell, with whom she forms a passionate friendship. Meanwhile, Douche plots his revenge on Frank while repairing himself in the trash can, driven by rage.
Frank’s journey leads him to the liquor aisle where he uncovers dark secrets from Firewater about the gods' cruelty, as well as the existence of a cookbook revealing the gruesome fates awaiting groceries. While learning these shocking truths, Frank returns to share his discoveries with the rest of Shopwell’s, but they are initially in denial of the grim reality of their existence.
As panic spreads throughout the store, a drug-induced encounter leads another sausage named Barry (Michael Cera) to desperately escape from a human who unearths his ability to hear and see the groceries. The chaos reaches its peak when an ill-fated accident turns the store into a battleground between groceries and shoppers.
Ultimately, upon enduring a series of catastrophic revelations, the remaining groceries come together for an unexpected celebration, only to later learn from Firewater and Gum (Scott Underwood), a brilliant wad of chewing gum with a mind like Stephen Hawking, that their identities as mere cartoon characters and voices of creators in another realm can grant them passage to meet their makers. The groceries, drawn by curiosity, decide to venture into this new dimension, propelling them into the unknown.
