Route 666

Route 666

Year: 2001

Runtime: 86 mins

Language: English

Director: William Wesley

ThrillerHorrorActionCrime drugs and gangstersHorror the undead and monster classics

Smith, a mob informant in Witness Protection, flees to the Arizona desert. Federal agents rescue him just before hitmen can silence him. While escorting Smith, the two agents take an abandoned stretch dubbed ‘Route 666’, named after a mysterious prison chain‑gang death. As they travel, they uncover the gang’s fate and the highway’s grim origin.

Warning: spoilers below!

Haven’t seen Route 666 yet? This summary contains major spoilers. Bookmark the page, watch the movie, and come back for the full breakdown. If you're ready, scroll on and relive the story!

Route 666 (2001) – Full Plot Summary & Ending Explained

Read the complete plot breakdown of Route 666 (2001), including all key story events, major twists, and the ending explained in detail. Discover what really happened—and what it all means.

In a sun-baked Arizona bar, Steven Williams portrays Fred “Rabbit” Smith, a witness who’s suddenly handcuffed by two federal marshals, Lou Diamond Phillips as Jack La Roca and Lori Petty as Steph, with orders to spirit Rabbit all the way to Los Angeles to testify against mobster Benny “The Buzzsaw” Buffalino. A deadly pursuit follows, as Sergei and his team of hitmen close in, forcing the marshals to summon a backup car crew that includes Nick, Mary, P.T., and Joe—the four charged with fending off the attackers until they reach safety. Nick is played by Alex McArthur, Mary by Mercedes Colon, P.T. by Dale Midkiff, and Joe by Rob Roy Fitzgerald. Together the group fights through the ambush, killing almost every pursuer but Sergei and continuing their tense trek toward Los Angeles.

As they push north, they learn of Route 666, a condemned strip running parallel to the famous Route 66 near the California border. The road’s grim history—built on a prison road crew accident—echoes in Jack’s memory, triggering a series of flashbacks about his own childhood: he was born nearby, his mother died when he was six, and his relationship with his father is only a memory.

On the highway’s edge, a county deputy named Gil Conaway spots the convoy and calls for backup, sparking a clash with the marshals. Jack shows his badge and Gil retreats, but not before the road reveals its strangest secret: a cemetery, and later the graves of four notorious 1960s killers—Miles Hackman, Frank Slater, Steve Pikowski, and John La Roca—whose spectral presence begins to weave into the night. The fate of Rabbit’s party grows darker when a moment of betrayal unfolds: Mary and Nick leave Joe to watch Rabbit, Sergei appears and shoots at Rabbit and Joe, and Joe is killed not by Sergei but by the undead remnants of the earlier killers.

The haunting continues as Nick drifts asleep in a car and is killed by Slater. Rabbit, handcuffed to a pole, escapes as Pikowski attacks, and he discovers the road’s rule: the undead can travel only on Route 666, surfacing from underground and moving along concrete. In a frantic turn, Jack dials 911 to reach Sheriff Conaway for help, giving him the Los Angeles marshal’s number and urging backup to reach them before more zombies arrive.

Flashbacks deepen the history: Jack sees his father, John La Roca, and the other notorious convicts at work on the road—Hackman, Slater, and Pikowski—while Hackman briefly escapes before a police officer forces them to dig another hole. In the present, Sheriff Conaway and his deputies close in, cornering Jack and Steph and their captured ally Gil inside a pickup area. Conaway murders Mary to force P.T. to reveal Jack’s location, and a violent struggle erupts as Conaway’s crew corner the survivors. The group frees Gil only to have the four zombies close in, killing Gil and leaving the survivors on the run.

A climactic confrontation unfolds when Jack, Steph, Rabbit, and Conaway collide with the resurrected convicts. The zombies pin Jack down, and a poignant revelation emerges when Jack admits to his father that he is his son; John La Roca then turns the tide, killing the last of the undead and lifting the road’s curse. The vengeful Sheriff Conaway reappears in the chaos, yet is outmatched as a ghostly road roller ends his pursuit. With the curse broken, Jack, Steph, and Rabbit walk toward Los Angeles, stepping beyond Route 666 into an uncertain dawn of freedom and a long, eerie road behind them.

Last Updated: October 09, 2025 at 15:28

Mobile App Preview

Coming soon on iOS and Android

The Plot Explained Mobile App

From blockbusters to hidden gems — dive into movie stories anytime, anywhere. Save your favorites, discover plots faster, and never miss a twist again.

Sign up to be the first to know when we launch. Your email stays private — always.

Unlock the Full Story of Route 666

Don't stop at just watching — explore Route 666 in full detail. From the complete plot summary and scene-by-scene timeline to character breakdowns, thematic analysis, and a deep dive into the ending — every page helps you truly understand what Route 666 is all about. Plus, discover what's next after the movie.

Route 666 Timeline

Track the full timeline of Route 666 with every major event arranged chronologically. Perfect for decoding non-linear storytelling, flashbacks, or parallel narratives with a clear scene-by-scene breakdown.

Route 666 Timeline

Characters, Settings & Themes in Route 666

Discover the characters, locations, and core themes that shape Route 666. Get insights into symbolic elements, setting significance, and deeper narrative meaning — ideal for thematic analysis and movie breakdowns.

Characters, Settings & Themes in Route 666

Route 666 Spoiler-Free Summary

Get a quick, spoiler-free overview of Route 666 that covers the main plot points and key details without revealing any major twists or spoilers. Perfect for those who want to know what to expect before diving in.

Route 666 Spoiler-Free Summary

More About Route 666

Visit What's After the Movie to explore more about Route 666: box office results, cast and crew info, production details, post-credit scenes, and external links — all in one place for movie fans and researchers.

More About Route 666

Similar Movies to Route 666

Discover movies like Route 666 that share similar genres, themes, and storytelling elements. Whether you’re drawn to the atmosphere, character arcs, or plot structure, these curated recommendations will help you explore more films you’ll love.