Year: 2008
Runtime: 97 mins
Language: Japanese
Director: Makoto Kamiya
Leon S. Kennedy and Claire Redfield must battle a rogue warrior seeking revenge after unleashing the deadly G-Virus, whilst a mutated monster goes on a rampage.
Warning: spoilers below!
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Read the complete plot breakdown of Resident Evil: Degeneration (2008), including all key story events, major twists, and the ending explained in detail. Discover what really happened—and what it all means.
Harvardville airport becomes the scene of a dual-front crisis in November 2005, as a fierce T-virus assault erupts both inside the terminal and on a stricken airliner. Claire Redfield, Alyson Court, a TerraSave worker, crosses paths with Senator Ron Davis, Michael Sorich, a vocal opponent of TerraSave, and the two find themselves scrambling to survive alongside Rani Chawla, Michelle Ruff, the niece of a TerraSave employee. By nightfall the facility is locked down, and local Special Response Team units along with the United States Army encircle the airport to rescue evacuated civilians. Officers Angela Miller, Laura Bailey, and Greg Glenn, Steve Blum, join the effort, with federal agent Leon S. Kennedy, Paul Mercier, arriving to support the operation. Claire’s group is saved, but they are forced to leave the infected Greg behind. WilPharma trucks appear, carrying a T-virus vaccine, only to be destroyed by explosives. A chilling slogan hangs over the chaos: a terrorist has vowed to unleash the T-virus nationwide unless government officials involved in its creation are exposed by midnight.
Claire accompanies Frederic Downing to WilPharma’s Harvardville research facility, where Downing hints at ambitions to develop a G-virus vaccine. Claire is unsettled by the prospect, and Downing’s departure leaves her uneasy. Claire soon informs Leon about Downing’s statements and learns that he and Angela have tracked down the burning home of her brother Curtis. Downing calls to warn Claire that a time bomb has been activated. In the central garden of the facility, Claire spots Curtis Miller, and soon the bomb detonates, forcing a desperate scramble to safety.
As the facility’s tension peaks, Leon and Angela part ways to pursue different leads. Leon reunites with Claire, while Angela reconnects with Curtis, who reveals the American government’s involvement in concealing Raccoon City’s destruction. After he injects himself with the G-virus, Curtis mutates and kills a squad of Marines. Leon saves Angela as the atrium garden begins to crumble, and the computer system triggers an incineration of the building to prevent the viruses from spreading. The two escape by diving into a pool to avoid lethal heat, and then slip into an underground area after breaking a glass partition to prevent drowning. Claire, meanwhile, reaches the command center, attempting to override alarms and reopen the building, but the moment Curtis is detected triggers an outbreak containment failsafe that sends the laboratory plummeting into the abyss to trap any infection.
Curtis lashes out again, viewing Leon as a threat and Angela as a possible mate. He regains control briefly and urges Angela to run before losing himself again. As the ejected sections of the structure spiral away, Leon and Angela cling to a broken catwalk, narrowly escaping. Curtis cannot hold on and tumbles to his death when a final shot from Leon seals his fate.
In the aftermath, Claire accuses Senator Davis of engineering the crisis to bolster WilPharma’s stock. Leon reveals that Davis is not behind the latest scheme; the real mastermind is Downing, who manipulated events to destroy the T-virus vaccine and mediate the recent bioterrorism incidents. Downing’s next move is debated—he speaks with General Grandé, a WilPharma client eager to acquire the T-virus, yet warns against using the G-virus. As Downing awaits a contact to sell WilPharma information, he mistakes a car carrying Leon and Claire for his buyer and is arrested by the police.
Downing later confesses to being a former Umbrella researcher who stole both the T-virus and the G-virus, escaping before the Raccoon City incident and assuming a new identity to sell the viruses while researching a vaccine. Angela notes that Downing manipulated Curtis, but Claire insists this does not fully clear him—his stated aim was to prevent another catastrophe like Raccoon City, a goal she, Leon, and Angela share.
News reports then reveal Senator Davis resigning amid insider trading allegations connected to WilPharma stocks. A newspaper draped over Davis’s face announces that Tricell Incorporated has offered to purchase WilPharma, and the company is shown assassinating Davis, erasing his files, and recovering G-virus samples from Curtis’s corpse. The crash of secrecy gives way to a larger, unresolved web of corporate and political intrigue as the bioweapons saga persists.
Last Updated: October 09, 2025 at 11:14
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