The story unfolds in the scenic west of Ireland, beginning with Pixie visiting her mother's grave, deeply engrossed in thoughts of avenging her death and longing for a distant escape. Concurrently, two inept criminals, Colin and Fergus, find themselves stopping outside a church, where Colin divulges his woes about a breakup with a girl named Pixie. This seemingly mundane moment quickly escalates when they enter the church and brazenly rob a bag filled with drugs at gunpoint, leading to a chaotic scene where a priest attempts to intervene, resulting in chaos and multiple deaths.
As the plot thickens, we find Pixie at the airport, eagerly awaiting someone she hoped to accompany on a flight to San Francisco. Meanwhile, Colin and Fergus are on the run after their heist when Colin discovers that Fergus is, in fact, the man Pixie has been seeing. Fueled by jealousy and rage, he reacts violently, shooting Fergus before hastily fleeing with the stolen drugs. Unbeknownst to Pixie, she heads home after failing to locate Fergus.
At the same time, two bumbling friends, Frank and Harland, sit in a bar discussing Pixie’s notorious charm and penchant for seduction, with Frank determined to pursue her. Later that evening, they end up outside Pixie's residence, where Frank ventures inside while Harland remains outside. Their evening takes a dark turn when Harland spots a furious Colin approaching with a gun. Acting on impulse, he runs Colin over with his car, leading to an unexpected twist as they conceal the body in their trunk and discover the drugs, leading them to hatch a plan to sell them for a quick profit.
Pixie's dilemma deepens as she realizes the drugs' connection to Father Hector McGrath, a menacing figure who orchestrates the criminal activities of corrupt priests. She then approaches Frank and Harland, warning them of the peril they'll face if they don’t act, cleverly manipulating them into aiding her to reclaim her stolen plans. As the narrative unfolds, we learn more about Pixie's past; through flashbacks, it is revealed that her mother suffered from stage IV cancer but was murdered by a dubious man before the disease could take her.
Determined to seek justice, Pixie sets her sights on a man named Jeremy Fisher, whom she discovers through hospital records, only to realize that it's an alias used by Colin. In a twist of fate, Colin's survival reveals new layers to the story as he attempts to hunt her down, but Pixie is ready. As they clash, she learns of his connection to her step-brother Mickey, revealing darker family ties and betrayal.
Pixie had initially intended to rob the church for funds, using Fergus and planning to eliminate Colin afterward, but her plans spiral as Colin escapes with the drugs. However, her luck changes when Frank and Harland unwittingly assist her. Their misadventures coincide with a showdown between her step-father's gang and Father Hector's crew, where Pixie finally confronts Mickey but chooses not to kill him, opting instead for a calculated escape with Frank and Harland.
In a final act of audacity, Harland sneaks back into the church to secure a bag full of money before the trio makes their getaway. In the film's closing moments, Frank and Harland bid an emotional farewell to Pixie at the airport. Just as she boards her flight, they come to the harsh realization of her treachery; she has outsmarted them, taking all the money for herself and leaving them none the wiser. The story culminates in a dramatic embrace of deception and moral ambiguity, encapsulating the essence of a cunning femme fatale navigating a world of chaos and crime.
