Osmosis Jones

Frank Detorre, a slovenly widower, displays numerous unhealthy habits that concern his young daughter, Shane. His compulsion for unhealthy food is highlighted when he eats a hard-boiled egg smeared with mayonnaise and salt, showing little regard for cleanliness.

During his grotesque meal, a mischievous chimpanzee at the zoo snatches Frank's hard-boiled egg, creating chaos. Frank's attempt to retrieve the egg results in its demise in the chimp's habitat, showcasing the wild nature of his environment.

Inside Frank's body, the white blood cell Osmosis 'Ozzy' Jones embarks on an unconventional mission. Known for his rebellious nature, Ozzy often clashes with fellow cells due to his disregard for protocols, which sets the stage for an adventurous narrative.

Ozzy finds himself in an embarrassing predicament at Shane's science fair when he mistakenly causes Frank to vomit on Shane's teacher, Mrs. Boyd. This incident prompts his reassignment to the mouth to deal with perceived threats.

Frank's mouth becomes a battlefield when germs hijack a squad car. This triggers an action-packed chase through Frank's body, highlighting the fighting spirit of Ozzy and his resolve to combat the invading germs despite facing rebukes from superiors.

A deadly virus named Thrax arrives, hitching a ride with Frank's hard-boiled egg. The situation escalates quickly as Thrax plots to masquerade as a mild cold while having sinister intentions to attack Frank's health.

Phlegmming, the mayor of germs, instructs Frank to take the Drix pill, meant to soothe irritation in his throat. Meanwhile, Ozzy reluctantly teams up with Drix, setting the stage for their shared journey to save Frank's body.

A climactic confrontation takes place in one of Frank's zits, where Drix activates a grenade filled with medicine. This resourceful move pops the zit, destroying many of Thrax's minions and showcasing the fight against internal threats.

Despite the victory in the zit showdown, Thrax attacks Frank's hypothalamus, undermining its ability to regulate body functions. This leads to an escalating crisis, with Frank's body temperature dangerously rising and hinting at dire consequences.

As chaos ensues within Frank's body, the escalating situation leads to a critical emergency trip to the hospital. Ozzy and Drix embark on a daring rescue mission to save Leah Estrogen, the mayor's secretary, who has been taken hostage by Thrax.

A gripping showdown unfolds on Shane's eyeball, where Ozzy intervenes just in time to thwart Thrax's lethal plans. His heroics ultimately lead to Thrax's demise, showcasing his growth from a rebellious cell to a true hero.

Amidst the turmoil, Frank's health declines drastically, spiraling into cardiac arrest. With the doctors seemingly at a loss, the urgency to act quickly heightens as the internal crisis continues to worsen.

In a moment of redemption, Ozzy returns to Frank's body carrying a tear from Shane, containing the missing hypothalamus chromosome. This act of love restores balance and life back to Frank, showcasing the emotional core of the story.

With the battle finally won, Ozzy and Drix are celebrated as heroes in Frank's immune system. Their success not only saves Frank's life but motivates him to adopt healthier habits moving forward.

In an ironic twist, Mayor Phlegmming faces a crushing defeat, being reduced to a janitor in the bowels as a consequence of his decisions. His accidental self-ejection by triggering a forbidden button highlights the fall from grace.