The story kicks off with Detective Vic Manning (Dave Bautista) and Detective Sara Morris (Karen Gillan) arriving at a hotel to apprehend the infamous drug lord Oka Teijo (Iko Uwais). However, Teijo surprises them, engaging in a fierce fight with Vic before making a narrow escape. In the heat of the moment, Morris attempts to gain control of her weapon, but Teijo shoots her in the abdomen, leading to a heart-wrenching scene where Vic rushes to save his partner, only to watch helplessly as she succumbs to her injuries.
Fast forward six months, we are introduced to Stu (Kumail Nanjiani), who juggles a job at a sporting goods store while moonlighting as an Uber driver. One of his challenging passengers is his annoying boss Richie Sandusky (Jimmy Tatro), who has a penchant for calling him “Stuber.” Meanwhile, Stu dreams of opening a spin class gym with his college crush Becca (Betty Gilpin), who is currently involved with a high-profile basketball player, leaving Stu feeling despondent. His struggle to maintain a stellar Uber rating adds to his stress, as poor ratings could cost him his job.
On the other hand, Vic is consumed by thoughts of revenge against Teijo for his partner's death. Despite his obsession, Captain Angie McHenry (Mira Sorvino) urges him to move on as the federal authorities are taking over the case. Just as Vic is about to get Lasik eye surgery, he plans to attend Nicole’s (Natalie Morales) art gallery exhibit that evening, even though his vision is impaired. In a twist of fate, Nicole helps him install the Uber app for convenience.
A dramatic turn of events occurs when Vic receives news from his informant Leon (Amin Joseph) about a heroin drop involving Teijo scheduled for that very night. Eager for revenge and justice, he attempts to drive to the meeting but ends up in a construction hole due to his poor eyesight. This forces him to call an Uber, which happens to be none other than Stu. What seems to be a fortunate circumstance rapidly spirals into chaos as they venture to a warehouse, only to discover Leon has been killed. Unbeknownst to Vic, he leaves bloody footprints behind as he takes Leon's phone, which connects him to Amber Titties (Amber Chardae Robinson).
Things escalate when Vic pushes Stu to keep driving toward Compton after learning that Leon was involved with a dealer named Amo Cortez (Rene Moran). Their journey leads them to a male strip club where confrontation unfolds, resulting in unintentional chaos. The stakes rise when they learn of a drug drop planned for later that night.
Their adventure becomes increasingly perilous as Vic's erratic behavior while interrogating Amo leads to an accidental gunshot wound to Amo's leg, further complicating their mission. Using an unconventional interrogation technique involving social media, they manage to extract crucial information about the drop. Yet, when Teijo's henchmen ambush them, they find themselves in a life-or-death scenario.
The duo's comic misadventures continue, including a misguided trip to a sporting goods store where tension culminates in a brawl between them and Richie. After a series of escalating confrontations and shocking revelations—including a plot twist involving McHenry as a dirty cop—the movie advances to a high-stakes showdown between Vic, Stu, Teijo, and the law.
As the climax unfolds, Nicole arrives just in time to save Vic from Teijo’s wrath, revealing unexpected twists regarding loyalties and heroism. The climax culminates in a dramatic hospital scene where emotions run high, and Vic expresses his gratitude to Stu for saving his daughter’s life.
The film concludes during the holiday season, showcasing a series of heartwarming resolutions. Becca's spin class gym thrives with Stu as her investor, while Vic finds solace with his rescued dog at a Chinese restaurant. An unexpected revelation about Stu and Nicole’s budding relationship leaves Vic astonished, wrapping up the narrative with a delightfully unexpected twist as they celebrate together. The closing scene features a festive wreath symbolizing Stu's success—a fitting end to their wild ride.
