Jack Halsey [Philip Winchester], his wife Lauren [Rebecca Romijn], and Lauren's two children Zoe [Isabel Bassett] and Noah [Michael Johnston], along with Zoe's boyfriend Billy, arrive at Amboseli Park in Kenya for a safari vacation. Jack [Philip Winchester] is worried about losing his job and the mounting expenses, and his constant grumbling puts a strain on the trip and on the family's dynamics, especially with Zoe [Isabel Bassett], who feels the pressure of his expectations.
Having canceled several activities to save money, Jack decides to take the family on safari without a guide, hoping to keep costs down. During the drive, he ignores a sign and enters a restricted area, unknowingly placing them between a rhinoceros and its calf. The animal charges, rams the van, and overturns it, injuring Jack's leg and shattering their water bottles. Lauren, who is a type I diabetic, discovers her insulin has been damaged in the chaos. The family scrambles to regroup as hyenas close in around them, forcing them to retreat into the van to hide.
Noah and Billy move toward higher ground in an attempt to get a cellphone signal. Before they can call for help, a leopard attacks Billy, leaving him badly injured and dragged away. Noah rushes back to the stunned van, but they decide to abandon it to avoid a second wave of danger. Meanwhile, Billy wakes in a tree with the leopard sleeping nearby. He manages to slip away and makes his way back toward the camp, only to find the vehicle abandoned and empty.
As they press on through the park, the family is surrounded again by a larger pack of hyenas; two men arrive, firing guns and scattering the predators. The family is led to safety at a makeshift camp. Around the campfire, Zoe notices a bloody elephant tusk and realizes the men are poachers. One of the men, Mitch [Jerry O'Connell], clashes with Jack, accusing him of hypocrisy for criticizing poachers while working in the oil industry—arguing that he is trying to help indigenous people benefit from their land rather than imposing foreign control. The realization that they are in danger grows as the men tie the family up and plan to kill them.
A sightseeing couple stumbles upon the van and rescues Billy, drawing attention away from the camp. Back at the campsite, Jack tearfully reconciles with Zoe and Noah, expressing his love for them and acknowledging that he can’t be their biological father but loves them as his own. He then manages to break free from his bonds, and Noah and Zoe work to move Lauren, who has slipped into unconsciousness from hours without insulin, into one of the poachers’ vehicles to keep her alive.
The poachers close in, catching up with Jack and shooting him, while Mitch pursues Zoe, Noah, and Lauren in another vehicle. After a brief chase, Mitch crashes his Jeep, stumbles out, and is soon surrounded by hyenas who kill him. An anti-poaching unit arrives, aided by Billy, and rescues the family. The wounded but recovering group spends time in hospital before visiting a wildlife enclosure for orphaned animals, a memorial dedicated to Jack for his bravery and devotion.
