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The film opens with Amy Winehouse running down the street, with her voice expressing her hopes for how people will interpret her music. This scene sets the tone for her ambitions and the emotional depth behind her artistry. It highlights her desire to connect to her audience through honest and heartfelt music.

Amy is shown at a family gathering, where she performs and receives encouragement from her Nan Cynthia. She also sings 'Fly Me to the Moon' with her father Mitch, indicating early musical interests and familial support. The event provides insight into her close family bonds and her developing talent.

In her room, Amy begins to express her thoughts and feelings through songwriting, starting with 'What Is It About Men.' This moment marks her early foray into creating music that reflects her personal experiences. It signals her desire to channel her emotions into her artistry.

Amy secures a deal with Island Records, leading to the release of her debut album 'Frank.' This milestone showcases her entry into the professional music world and her initial rise to fame. Her raw talent begins gaining recognition within the industry.

During a meeting with record executives, Amy is advised to modify her stage presence to appeal to a broader audience, notably by not playing guitar while singing. She refuses and asserts her authenticity, emphasizing her independence and artistic integrity before requesting time off to find inspiration.

Amy encounters Blake Fielder-Civil while at a pub, where they bond over music and spend the afternoon together. Despite Amy discovering Blake already has a girlfriend, a romantic connection begins to form, setting the stage for their tumultuous relationship.

While dealing with her personal struggles, Amy privately battles bulimia. She confides in her Nan Cynthia, who reveals she has lung cancer. Amy's emotional response shows her vulnerability and the mounting pressures in her life.

Amy collaborates with producer Mark Ronson and adopts her iconic beehive hairstyle. She travels to New York City to work on the album 'Back to Black,' inspired by her tumultuous romantic experiences and personal darkness.

After a romantic reconciliation, Amy and Blake marry, expressing her desire to be a wife and mother. Mitch reacts skeptically to her impulsive decision, highlighting family concerns about her choices.

Amy struggles with heavy drug use and alcoholism, worsening her mental health. Her performances become inconsistent, and incidents like shoving a fan and punching Blake reveal her unstable state amidst substance abuse.

After hitting her head during a blackout and being advised by her team, Amy refuses to enter rehab. Her substance abuse persists, and her health continues to decline as she spirals deeper into addiction.

Amy overcomes her addiction publicly by performing 'Rehab' via satellite at the Grammys, winning five awards. This moment signifies her journey towards recovery and acknowledgment by the industry, highlighting her resilience.

Moving to a new home, Amy reflects on her life and loss, saying goodbye to her mother and facing the reality of Blake's new life with his wife and child. She sings 'Tears Dry on Their Own' mournfully, encapsulating her profound grief and loneliness.

The film concludes with the somber note that Amy died at age 27 on July 23, 2011, from alcohol poisoning after a period of sobriety. Her death underscores the tragic toll of addiction, leaving a lasting legacy through her soulful music.