Dr. R.J. "Roscoe" Stevens, better known as Roscoe Jenkins, is a prominent talk-show host who enjoys a massive fan base while having left behind his awkward Southern origins. He is set to marry Survivor champion Bianca Kittles. However, when Roscoe reluctantly takes Bianca and their 10-year-old son, Jamaal, back to his quiet Southern hometown to celebrate his parents' 50th wedding anniversary, he's determined to demonstrate that he’s shed his past as a family outcast.
Upon arriving in Georgia, Roscoe encounters his cousin Reggie, a pickpocket, along with his girlfriend Amy. He is welcomed back by his boisterous family: his parents Roscoe Sr. and Mama Jenkins, his sheriff brother Otis, Otis' wife Ruthie, their rambunctious kids Junior and Callie, and his wild sister Betty. The unexpected arrival of cousin Clyde rekindles a longstanding rivalry, and the presence of Lucinda, an old flame, complicates matters further. Despite nearly a decade of success away from home, Roscoe's attempts to impress his family with his wealth and accomplishments quickly backfire, exposing the insecurities hidden beneath his glamorous facade.
As events unfold, Roscoe endures a string of embarrassing incidents: he inadvertently hits his mother with a softball during a game, finds himself beaten up by Otis and Betty after a thoughtless comment, faces relentless blackmail from Reggie, ruins the family fish fry with a brawl, and is doused by a skunk while sleeping. Strained relationships between Roscoe and his father are brought to light, revealing a deep-seated resentment stemming from his father's favoritism towards Clyde. Meanwhile, Bianca struggles to fit in with the Jenkins family, creating additional tension.
During the anniversary celebration, a traditional obstacle course brings the family together in a chaotic showdown between Roscoe and Clyde. As Roscoe begins to help Jamaal, Bianca insists he abandon his son to focus on winning. Roscoe's choice to compete against Clyde astounds his family, culminating in his victory, reminiscent of his triumph two decades prior. However, in the heat of the moment, Roscoe adopts a brash attitude, emphasizing that “it’s all about the team of me.” This alienates his family and leaves Jamaal disillusioned with his father's arrogance.
Amidst rising conflicts, Roscoe confronts his father about their troubled relationship, revealing feelings of abandonment due to Roscoe Sr.'s favoritism towards Clyde. This heartfelt moment leads to a realization that both Roscoe and Clyde have felt the pressures of family expectations. Roscoe, despite some unresolved issues, recognizes the importance of family love.
As Roscoe prepares to depart with Bianca and Jamaal, a thoughtful but contentious discussion about family involvement in their upcoming wedding emerges, leading to Roscoe's decision to leave Bianca behind at the airport. He returns home to the Jenkins family, bringing along a Pomeranian named Fifi, who had developed a bond with the family's aging Labrador, Bucky.
During the heartfelt anniversary celebration, Clyde expresses his affection for the Jenkins family, revealing how much their support has meant to him. Inspired by the love surrounding him, Roscoe acknowledges his own feelings and extends an olive branch to his father. Their emotional reconciliation signifies a turning point in their fractured relationship. Ultimately, Roscoe reconnects with Lucinda for a dance, and as the family gathers to relive the celebration's moments on screen, Roscoe's comedic misadventure continues as he attempts to navigate his newfound connections—and the antics of their pets—amidst laughter and joy. During the credits, viewers see Roscoe interviewing his family on his newly rebranded show, The Roscoe Jenkins Show.
