The story unfolds in the vibrant city of Los Angeles during the summer of 1977. A curious young boy named Bobby (played by Ty Simpkins) decides to sneak into his father's room, where he discovers a hidden adult magazine. As he gazes at the stunning centerfold of adult film star Misty Mountains (portrayed by Murielle Telio), an unexpected incident occurs—a car unexpectedly rolls down a hill, crashes into Bobby's house, and comes to a halt in a ditch. When Bobby rushes outside to investigate, he finds Misty lying nude not far from the wreck. In a haunting moment, she asks him, > "How do ya like my car, big boy?" before taking her last breath. Overcome with shock, Bobby tenderly covers her with his shirt.
We are then introduced to Jackson Healy (Russell Crowe), a tough enforcer on the lookout for a man who has been involved with a 13-year-old girl. After confronting the man and delivering a punishing blow, Healy warns him to steer clear of minors.
Meanwhile, Holland March (Ryan Gosling), a down-and-out private investigator, finds himself indulging in a bubble bath wearing his suit, with the words "You will never be happy" scrawled on his hand. Struggling with alcoholism after the death of his wife, March's life is complicated further as he takes care of his daughter, Holly (Angourie Rice). One day, he meets an elderly woman who believes her husband has gone missing, but the discovery of a familiar urn puts a comically dark twist on his next case.
Healy’s path crosses with a rebellious teenager, Amelia (played by Margaret Qualley), who provides him with March's name and address, leading to confusion and a wild chase to uncover the truth behind a missing girl.
As destiny intertwines their fates, March and Healy reluctantly join forces to solve the mysteries surrounding Amelia and Misty's intertwined destinies, eventually leading them into a labyrinth of danger, conspiracy, and a shocking revelation about the adult film industry that connects back to the government. The duo's investigation leads them through raucous parties filled with colorful characters, unexpected brawls, and moments of comedic relief, including a near-fatal chase involving accidentally misplaced firearms—a testament to their clumsy synergy.
Their harrowing journey brings them face to face with Judith Kuttner (Kim Basinger), who reveals the ominous connection between Amelia's film and a mob conspiracy aimed at controlling the porn business in Los Angeles. Amidst the chaos, Holly becomes a crucial part of the story, showcasing brave acts that create intense stakes.
As the climax approaches, the three unlikely allies discover that uncovering the truth about Amelia's project could expose the corrupt forces in power. With clever thinking and a fair share of luck, they navigate an explosive showdown filled with unexpected twists that lead to justice, albeit not entirely unscathed.
The movie expertly blends humor, action, and mystery, showcasing a witty script and captivating performances, especially from the dynamic duo of Healy and March as they confront their own flaws while tackling external dangers. When the dust settles, the evolving friendship between the three continues in a tantalizing direction, suggesting more misadventures awaited them in the future. The film concludes with March contemplating their next case, humorously hinting at the birth of their detective agency, aptly named "The Nice Guys."
