After a harrowing battle with the Tiktiks in the town of Pulupandan, Makoy, along with his wife Sonia, their newborn son Mackie, Sonia's father Nestor, and their neighbor Pacing, attempt to leave their past behind. Unfortunately, they fall prey to a new set of aswangs known as Kubot, led by the menacing Veron. In a brutal ambush, Veron kills Sonia and Pacing, abducts baby Mackie, and viciously injures Makoy by cutting off his hand. Despite the chaos, Makoy and Nestor narrowly escape after a dramatic bus explosion.
Fast forward two years, Makoy and Nestor are trying to rebuild their lives as mechanics in a bustling Manila, sharing their small home with Makoy’s older sister Nieves and her daughter. Amidst their struggles, Makoy has adapted to his new life with a prosthetic arm, crafted by engineering students Stacey and Benjie.
Nieves, working as a secretary for a physician named Lex, grows suspicious of her boss’s questionable medical practices. One fateful night, she decides to eavesdrop on Lex's after-hours work, only to discover a shocking scene—Lex is torturing a patient in a shocking twist of fate. The truth unfolds as Lex explains her own investigation into a puzzling number of people transforming into aswangs. Their conversation is abruptly interrupted when Lex's home is ravaged by an attack from aswangs, leading to the tragic death of her family. Both women flee back to Nieves' home.
As they regroup, Lex reveals a disturbing secret: tainted processed meat from Dom's hotdogs is responsible for these transformations. Hope for a resolution seems all but lost when Makoy and Nestor refuse to help upon learning of Lex’s true nature as an aswang. Unfazed, Nieves and Lex return to Lex's home, where they find themselves embroiled in a police investigation regarding the horrific demise of Lex's family.
In a twist of fate, the aswangs return with intentions of capturing Lex. Makoy and Nestor arrive just in time to offer assistance. However, as additional police force floods in, a chaotic scene ensues—Makoy and Lex manage to escape, while Nieves and Nestor find themselves behind bars. They pull off a miraculous proof of innocence using Tope, a corrupt meat inspector turned aswang, captured during the fray. The police, including Justiniani and Macapagal, resort to torturous methods to extract information about the aswangs’ whereabouts.
The plot thickens as Makoy and Lex receive aid from Lex's tribal companions, although tragedy strikes when Makoy is shot by gangsters during their escape. Lex is there to tend to his injuries, and soon, the tribe urges him to depart, especially with an elder aswang set to arrive for guidance in their battle against Dom. A tense confrontation follows as Makoy faces Veron, the elder leader of the Kubot, who surprisingly decides to ally with him against Dom, rather than kill him.
Returning to Nieves' home, Makoy finds both Nestor and Nieves trying to persuade him to thwart Dominic's sinister operations. Initially resistant, he comes to his senses upon learning of a free concert sponsored by Dom’s hotdogs set for that evening. Together with Nestor and Nieves, they concoct a plan to halt the distribution of the dangerous hotdogs. With a new arm at his disposal, Makoy prepares for the impending showdown.
In a dramatic turn of events, Lex and Veron confront Dom about the missing council members; Dom shockingly confesses to their murders and captures the two. As Justiniani and Macapagal raid Dom’s factory, they fall into his trap, facing dire consequences. Yet, through Makoy's ingenuity, they manage to escape, allowing Nestor and Nieves to thwart the meat shipment while Lex and Veron handle Dom's minions. In an epic climax, Makoy confronts Dom, who initially overpowers him. However, drawing strength from Nieves’ words about bravery, he finds the resolve to vanquish Dom in an intense battle.
Following the collapse of Dom's hotdog enterprise, Veron returns Mackie to Makoy's workshop. As Nieves lovingly cradles the boy, Nestor discovers a nametag identifying him as Mackie, revealing the unexpected twist that Veron had not killed the child, but had instead taken him under her wing. The aftermath sees Dom's family mourning their loss, while his grieving mother is comforted by Dom's wife, who vows revenge on Makoy, hinting at unresolved tensions and a lingering threat that may persist.