Ashok, portrayed by Saif Ali Khan, and Kumar, played by Ritesh Deshmukh, share a deep friendship, while Shanaya, enacted by Tamannaah Bhatia, and Mishti, brought to life by Bipasha Basu, capture their hearts. The story unfolds as Ashok's wealthy father remains in a coma after six years, creating a ripe opportunity for his sinister Mamaji, portrayed by Ram Kapoor, who conspires with the malevolent Dr. Khan, played by Nawab Shah. Their scheme centres around ensuring Ashok meets a similar fate to his father, as the estate would fall into charity if he dies, forcing them to plot his incapacitation or declare him mentally unstable.
In a twist during a board meeting, Mamaji spikes Ashok and Kumar's drinks, transforming them into dog-like behavior for a full day. This bizarre event leads to their admission into a mental asylum under the care of Dr. Shivani, played by Esha Gupta. However, Dr. Shivani quickly uncovers the truth about their situation and intends to release them. Yet, fate takes another turn when two lookalikes of Ashok and Kumar are mistakenly set free from the 'B' ward of the asylum. These duplicates are associated with Bijlani, a cocaine trafficker portrayed by Chunkey Pandey, whose antics with the drug create further chaos.
Shanaya and Mishti, believing they have returned with Ashok and Kumar, invite the imposters to Ashok's lavish mansion. Mamaji seizes this opportunity to manipulate the situation to his advantage, planning to use the fake Ashok to appropriate Ashok’s business empire. Meanwhile, the genuine Ashok and Kumar, confined in the asylum, learn about Mamaji's nefarious plot. With the help of a resourceful ward boy named Cyrus, played by Darshan Jariwala, they find a way to meet Johnny, a Mamaji lookalike with a peculiar and violent reaction to sneezing.
Together, Ashok, Kumar, and Johnny devise a plan for revenge against the duplicitous Mamaji. However, their efforts lead to a delay when they are caught by the warden Y. M. Raj, played by Satish Shah, who inadvertently sneezes, igniting Johnny's aggressive tendencies and allowing the trio to make their escape.
On the critical day of the board meeting, the chaos continues as Ashok and Kumar find themselves entangled in a farcical fight against their uncle, highlighted by a hilarious series of mix-ups that force them to confront Mamaji's true identity amid the corporate chaos. As Dr. Khan disrupts the meeting by triggering a fire alarm, a spectacular series of mishaps ensues, leading Ashok and Kumar to inadvertently encounter their triplicate selves and another Mamaji, all converging at the House of Commons to create pandemonium during a presentation to Prince Charles.
The climax culminates with Ashok’s father astonishingly awakening from his coma, reclaiming his identity, and bringing Mamaji to justice for his outrageous schemes and manipulations, effectively tying up the absurd yet entertaining narrative that leaves audiences both laughing and captivated.
