Brain on Fire

Susannah Cahalan, a 21-year-old writer, begins experiencing symptoms resembling the flu. What starts as a persistent cough and fatigue quickly escalates into unexplainable behavior, marking the beginning of her medical struggles.

As Susannah’s illness progresses, she displays strange behaviors, including trance-like states where she hears non-existent voices and becomes sensitive to loud noises. These baffling symptoms raise concern among her family and friends.

A seizure forces Susannah to seek help after her family realizes the severity of her condition. However, the doctor initially dismisses her symptoms as fatigue from overworking and partying too much, leading to frustration.

In search of comfort and care, Susannah moves in with her mother, Rhona. The emotional strain of her deteriorating health takes its toll, ultimately leading to another seizure that necessitates hospital admission for further tests.

Susannah grapples with her declining mental health, questioning whether she might have bipolar disorder due to extreme mood swings. This internal conflict complicates her already challenging situation as she seeks a proper diagnosis.

As Susannah's erratic behavior challenges her mother’s ability to care for her, she moves to live with her father, Tom, and his fiancée. This relocation adds another layer of complexity to her already turbulent life.

During a dinner, Susannah's outburst turns violent, raising alarm among her parents. This incident convinces them to insist on hospitalization despite previous normal test results, propelling her further into the healthcare system.

While in the hospital, various tests including MRIs and EEGs yield no conclusive results. One doctor begins to consider the possibility of schizophrenia, creating a sense of urgency and fear for Susannah's future.

As Susannah's condition worsens, her parents seek the expertise of Dr. Najjar. He conducts an investigation that includes a disturbing clock-drawing test, revealing troubling signs that hint at a serious neurological issue.

A brain biopsy provides the shocking diagnosis of anti-NMDA receptor encephalitis, described by Dr. Najjar as 'a brain on fire.' This diagnosis finally offers an explanation for Susannah's troubling symptoms and opens the door to potential treatment.

With the diagnosis in hand, Dr. Najjar initiates treatment that includes immune therapies. This marks the pivotal moment in Susannah's journey, as she begins to show signs of recovery from her debilitating condition.

After seven months of recovery, Susannah joyfully returns to her job at The New York Post. She presents her first article since her health crisis, which reflects her journey and resilience.

Encouraged by her boss, Susannah embarks on writing a memoir titled 'Brain on Fire' to share her harrowing experiences. This project serves both as a therapeutic outlet and a means to raise awareness about her condition.

The film concludes by revealing that Susannah is the 217th person diagnosed with anti-NMDA receptor encephalitis. Her memoir has since inspired many others facing similar struggles, resulting in increased diagnoses and better treatment options.

Susannah maintains a close friendship with Dr. Najjar, reflecting on their shared journey through her health crisis. This connection underscores the importance of understanding and support in overcoming life-altering challenges.