Splice

Splice

Year: 2010

Runtime: 104 min

Language: English

Director: Vincenzo Natali

Sci-FiThrillerHorror

Driven by ambition and a desire to advance genetic research, two scientists create a unique life form by splicing together human and animal DNA. As their creation rapidly develops and exhibits unexpected abilities, the researchers grapple with the ethical implications of their work and the potential dangers they've unleashed. Their relationship is tested as they struggle to control the increasingly complex being, leading to unforeseen consequences.

Warning: spoilers below!

Haven’t seen Splice yet? This summary contains major spoilers. Bookmark the page, watch the movie, and come back for the full breakdown. If you're ready, scroll on and relive the story!

Timeline – Splice (2010)

Trace every key event in Splice (2010) with our detailed, chronological timeline. Perfect for unpacking nonlinear stories, spotting hidden connections, and understanding how each scene builds toward the film’s climax. Whether you're revisiting or decoding for the first time, this timeline gives you the full picture.

1

Breakthrough in Genetic Engineering

Clive Nicoli and Elsa Kast gain recognition as leading genetic engineers after successfully splicing different animal DNA. Their groundbreaking work piques the interest of a pharmaceutical company, N.E.R.D.

2

The New Direction

Despite their success, N.E.R.D. directs Clive and Elsa to focus on mundane research rather than their dream project of creating a hybrid with human DNA. Frustrated by this limitation, they secretly decide to pursue their ambitions on their own.

3

Creating Dren

Clive and Elsa manage to splice human and animal DNA, culminating in the birth of their hybrid creature, Dren. As Dren grows at an astonishing rate, Clive and Elsa become increasingly attached to their creation.

4

The Move to the Farm

As Dren's presence complicates their work, Clive and Elsa decide to move her to Elsa's late mother's farm for safety. This transition reflects their growing investment in Dren, but it also escalates the risks they face.

Elsa's late mother's farm
5

The Catastrophic Presentation

During a crucial shareholders' meeting, Clive and Elsa's earlier hybrid animals engage in a violent confrontation when one unexpectedly changes sex. The bloodshed shocks the audience and jeopardizes N.E.R.D.'s reputation.

N.E.R.D. headquarters
6

Dren's Transformation

Dren undergoes multiple transformations, developing amphibious traits and aggressive behavior, which includes an encounter that results in her killing Elsa's pet cat. This event solidifies Elsa's growing concern about Dren.

7

Elsa's Decision

After witnessing Dren's violent outburst, Elsa finds herself torn between maternal instincts and the realization of the danger Dren poses. She chooses to cut off Dren's stinger, finally isolating the vital protein they were seeking.

8

Clive's Betrayal

In an unexpected turn, Dren attempts to seduce Clive, leading to an intimate encounter between them. Elsa confronts Clive about this betrayal amidst shocking revelations regarding Dren's DNA origin.

9

The Apparent Death of Dren

Clive and Elsa return to the farm to find Dren seemingly dead in a water tank. They mourn her loss and decide to bury her, unaware of the true nature of Dren's condition.

Elsa's late mother's farm
10

Dren's Return

Just as Clive and Elsa deal with their grief, Dren shockingly reveals she was never dead but rather had entered a state of transformation. Attacking violently, Dren kills Clive's boss and thrusts Clive into danger.

Elsa's late mother's farm
11

The Final Confrontation

Following a chaotic series of events, Dren assaults Elsa, and Clive battles to save her. In a climactic struggle, Clive is killed by Dren, but Elsa finally manages to deal a fatal blow to Dren.

Elsa's late mother's farm
12

New Beginnings

In the aftermath of Dren's death, Elsa meets with the head of N.E.R.D. She is offered a significant sum in exchange for her silence regarding the experiments, as well as a chance to continue her work.

N.E.R.D. headquarters
13

A Shocking Revelation

As the deal concludes, Elsa stands up to leave, revealing her pregnancy, a chilling reminder of her bond with Dren. This revelation leaves the future uncertain and hints at the possibility of continuing the cycle of experimentation.

Last Updated: May 13, 2025 at 20:30

Unlock the Full Story of Splice

Don't stop at just watching — explore Splice in full detail. From the complete plot summary and scene-by-scene timeline to character breakdowns, thematic analysis, and a deep dive into the ending — every page helps you truly understand what Splice is all about. Plus, discover what's next after the movie.

Splice Summary

Read a complete plot summary of Splice, including all key story points, character arcs, and turning points. This in-depth recap is ideal for understanding the narrative structure or reviewing what happened in the movie.

Splice Summary

Characters, Settings & Themes in Splice

Discover the characters, locations, and core themes that shape Splice. Get insights into symbolic elements, setting significance, and deeper narrative meaning — ideal for thematic analysis and movie breakdowns.

Characters, Settings & Themes in Splice

More About Splice

Visit What's After the Movie to explore more about Splice: box office results, cast and crew info, production details, post-credit scenes, and external links — all in one place for movie fans and researchers.

More About Splice

Similar Movies to Splice

Discover movies like Splice that share similar genres, themes, and storytelling elements. Whether you’re drawn to the atmosphere, character arcs, or plot structure, these curated recommendations will help you explore more films you’ll love.