South Park: The End of Obesity

A doctor informs fourth grader Eric Cartman and his mother Liane that his obesity poses a serious health risk. The doctor suggests trying a diabetes drug called semaglutide to help with weight loss, emphasizing its effectiveness in some cases. Liane expresses skepticism, stating that diet and exercise haven't worked for Cartman before.

Cartman begins to fantasize about using semaglutide to insult people without fear of mockery, imagining himself cruelly shaming others and even considering traveling to Pakistan to continue this behavior. His daydreams reflect his desire for social dominance and relief from being bullied about his weight.

Since insurance only covers semaglutide for diabetes treatment, Liane finds the drug too expensive for Cartman to afford. This obstacle prompts them to seek alternative solutions, as the medication's primary use does not make it accessible for weight loss in their situation.

Cartman's friends Butters and Kyle join him when they visit an insurance company office to make a claim. They face a complex and frustrating journey through the healthcare system's bureaucracy, trying to find a way to get the medication for Cartman.

The kids discover that raw semaglutide powder can be bought cheaply from a factory in India and mixed locally with biostatic water. They decide to produce it themselves as a more affordable alternative, inviting Stan and Kenny to join their risky scheme.

Randy Marsh notices local mothers wearing crop-tops after losing weight with semaglutide. Inspired, he wears his daughter's crop-top to embarrass her, which leads him to try the drug himself, believing it to be a party drug that suppresses appetite and eliminates hangovers.

Sharon begins taking Lizzo's music to encourage body positivity but ends up experiencing severe side effects, including constipation from her ears, dubbed 'diabeardes'. Her condition makes her eligible for semaglutide treatment, and the doctor prescribes it to her.

Kyle delivers a speech advocating for an end to fat shaming, gaining community support. Meanwhile, Cartman's homemade semaglutide appears to be effective, prompting Kyle to produce more to help those who cannot afford the medication, attracting negative attention from a sugar industry cartel.

A government crackdown on semaglutide abuse leads to thefts from pharmacies, and sugar mascots posing as body positivity activists attack the Indian factory, murdering workers and burning the building down in retaliation. Kyle manages to acquire more powder from another supplier in North Carolina.

The truckload of semaglutide powder is carjacked by Randy and local mothers, but Randy realizes their intentions are wrong and steals it back during a chaotic chase involving the boys and sugar mascots. Kenny is tragically killed during the pursuit when hit by Tony the Tiger.

When they open the truck, the group finds only the insurance claims agent inside, who reveals that the insurance company collaborates with the drug supplier. This means another complicated step through the healthcare system is required to access semaglutide.

Randy confesses to Sharon that he has been taking semaglutide himself. She responds with understanding and support, leading Randy to realize she is the 'coolest woman he knows. He then invites her to a holiday inn to relive their college days and take MDMA together.

Encouraged by his success with weight loss, Cartman gives a speech at school advocating for the end of fat shaming. He then books a flight to Pakistan, eager to continue insulting others without fear, reflecting his desire for social dominance and validation.