Following a devastating nuclear holocaust, the planet has devolved into a barren wasteland where civilization has crumbled. Max Rockatansky (Tom Hardy), a resilient survivor, finds himself captured by the ruthless War Boys, the army of the tyrannical Immortan Joe (Hugh Keays-Byrne). Max is taken to Joe's formidable stronghold known as the Citadel, where he’s designated as a universal blood donor and confined as a "blood bag" for a gravely ill War Boy named Nux (Nicholas Hoult).
In the meantime, Imperator Furiosa (Charlize Theron), one of Joe's top lieutenants, sets out in her formidable armored truck—referred to as a "war rig"—alongside a small unit of War Boys, on a mission to secure a considerable fuel supply from a nearby settlement, known as Gas Town. However, as she veers off the expected route, Joe realizes that his five wives, chosen for breeding purposes, are missing. Enraged, he mobilizes his entire army in pursuit of Furiosa, seeking assistance from both Gas Town and another community called the Bullet Farm.
Nux, among the most skilled drivers of the War Boys, joins the chase with Max strapped to the front of his vehicle, needing his blood transfusions to keep Nux alive. A fierce battle breaks out involving the war rig, the Buzzards gang, and Joe's forces. While Furiosa's War Boys manage to fend off the Buzzards, Joe's relentless army refocuses their efforts on obstructing Furiosa's escape. In a desperate maneuver, she plunges into a sandstorm, momentarily evading her pursuers, except for Nux, who attempts to destroy her truck as an act of sacrifice. In a tense moment, Max intervenes to restrain Nux, resulting in the destruction of the vehicle.
Emerging from the storm, Max discovers Furiosa repairing her truck, accompanied by Joe's wives: Capable (Riley Keough), Cheedo (Courtney Eaton), Toast (Zoë Kravitz), the Dag (Abbey Lee), and Angharad (Rosie Huntington-Whiteley), who is heavily pregnant with Joe's child. In a moment of chaos, Max overpowers Furiosa and attempts to commandeer the truck only to realize its kill switch has rendered it immobilized. Left with no choice, he reluctantly agrees to aid Furiosa on their journey, while Nux is collected by Joe's army.
As Furiosa navigates through a canyon dominated by the ruthless Rock Riders, she attempts to negotiate for safe passage. However, under the threat of Joe's forces, the bikers turn on her, forcing a hasty retreat as they collapse canyon walls to obstruct Joe's fleet. Amidst the conflicted skirmish, Joe's car eventually overcomes the blockade, allowing Nux to board in the melee. Tragically, during the escape, Angharad falls from the truck while trying to protect Max, resulting in her being fatally injured by Joe's vehicle. Despite the efforts of Joe's medic, the Organic Mechanic, the unborn child does not survive, infuriating Joe further upon discovering it was a boy.
Furiosa then reveals to Max that they are seeking the mythical "Green Place," a lush land she fondly remembers from her youth. As Capable finds Nux hiding, overwhelmed by his sense of failure, she comforts him. That night, their truck becomes ensnared in thick mud. While Furiosa and Max slow down Joe's relentless pursuit by planting mines, Joe's ally, the Bullet Farmer (Richard Carter), continues to chase them down. Nux aids Max in freeing the truck, while Furiosa takes aim and blinds the Bullet Farmer.
In a clever twist, Nux discovers that by utilizing a nearby dead tree with the war rig's winch, they can escape the mud. Meanwhile, Max confronts the Bullet Farmer and his gang amidst explosions and flashiness in the distance. When he returns covered in the blood of their assailants, he brings weapons, ammunition, a boot for Nux, and a lost steering wheel from the earlier battle.
Continuing their arduous trek through swampland and desert, they stumble upon a naked woman the following day. While Max suspects a trap, Furiosa engages her in conversation, establishing her clan ties. The woman then calls forth her clan, the Vuvalini, who recognize Furiosa, revealing her identity as one of their own who had been abducted. To Furiosa’s heartache, she learns that the area they had previously traversed, which she believed to be the Green Place, is now desolate. The group resolves to traverse the immense salt flats on motorbikes, a daunting journey requiring at least 160 days.
Initially intent on remaining behind, Max chooses to join them after grappling with haunting visions of a child he was unable to save. He persuades the group to return to the unguarded Citadel, which houses an abundance of water and greenery that Joe hoards for himself, planning to trap Joe and his forces in the canyon controlled by the Rock Riders.
As they journey back to the Citadel, they are unexpectedly attacked by Joe's army. In a valiant display, several members of the Vuvalini fall while valiantly defending the group, leaving Furiosa seriously injured. Joe positions his vehicle in front of theirs to hinder their escape, culminating in a brutal combat between Max and Joe’s gigantic son, Rictus Erectus. During this climactic battle, Joe captures Toast, but she utilizes a moment of distraction to allow Furiosa to rip off his breathing mask, leading to his demise.
In a selfless act, Nux sacrifices himself by wrecking their truck, killing Rictus and effectively blocking the canyon, which permits Max, Furiosa, the wives, and the Vuvalini to escape in Joe’s vehicle. In a moment of brilliant camaraderie, Max transfuses his blood to help Furiosa stand against her injuries, and while doing so, he finally reveals his name to her.
As they arrive back at the Citadel, a wave of jubilation sweeps through the impoverished citizens at the sight of Joe's lifeless body. Furiosa, alongside the wives and the Vuvalini, receives a warm welcome from the War Boys and the residents. In a quiet farewell, Max walks away, sharing a poignant glance with Furiosa before disappearing into the crowd.
