Thurgood, portrayed by Dave Chappelle, along with his childhood friends Scarface, played by Guillermo Diaz, Brian, and Kenny, navigate the ups and downs of adulthood after discovering the world of marijuana. Set in a bustling New York City, the four friends grow up in a lively apartment, where one fateful day, they send Kenny out for food during a smoke session. In a twist of events, Kenny encounters a horse and, in a moment of kindness, starts feeding it treats—unbeknownst to him, the horse is diabetic. Tragically, the horse dies, leading to Kenny's arrest with a staggering bail set at $1,000,000.
Things take an interesting turn when a striking woman named Mary Jane Potman, played by Rachel True, gives them a ride home, capturing Thurgood's heart instantly. In a desperate move to raise funds for their friend’s bail, the group decides to sell medicinal marijuana that Thurgood receives from a scientist. This entrepreneurial venture leads to unexpected success, attracting a plethora of eccentric customers, including personalities like John Stewart, Snoop Dog, Willie Nelson, Stephen Baldwin, and many others.
As Thurgood tries to keep his moral compass steady, Brian and Scarface abandon their jobs to fully immerse themselves in their burgeoning weed business, which rapidly spirals out of control. Thurgood even goes on a romantic date with Mary Jane, vowing to quit smoking, yet he soon finds himself incapable of keeping that promise.
When Mary Jane ultimately breaks up with him, Thurgood vows to change his habits, but the situation escalates when a rival drug dealer, Samson, catches wind of their operation. The confrontation leads to their apartment being ransacked, as Samson imposes a demand for half of their profits. In a moment of desperation, the suggestion arises to rob the lab for more weed, but their plan flops spectacularly when they get caught.
To turn the tides, Thurgood concocts a plan to set up Samson with the help of the police. In a humorously absurd twist, the cops allow the guys to get high before the inevitable bust, leading to a lapse in their memory about the operation. After an intense showdown with Samson’s henchwomen, Brian even channels the spirit of Jerry Garcia to rally the crew against their foes.
Ultimately, justice prevails as the police honor the deal to release Kenny, and Thurgood makes amends with Mary Jane, choosing to leave his marijuana days behind for good, delivering a sweet conclusion to their wild adventure. The story captures the essence of friendship, love, and the humorous mishaps that often accompany growing up.
