Philandering Hollywood writer Charlie Sorel is shot and killed by Hungarian film producer Sir Leopold Sartori when he is caught fooling around with Sartori's wife Rusty. Charlie's best and only friend, novelist George Wellington Tracy, arrives at Charlie's Malibu beach house for the memorial service after an exhausting series of flights from Paris that have left him broke. There are only three people there: Charlie's agent and two ex-girlfriends. George does his best to eulogize his friend, but there is little to be said in favor of Charlie, whose final bad joke on George is making him executor of his estate, a mess of debts and unpaid taxes.
Soon after the guests leave, an exhausted George is awakened by a knock at the terrace door and the appearance of Bruce Minton III assisting a petite blonde woman swathed in a huge brown overcoat. Bruce, played by Bruce Minton III, came to her aid when he found her dazed and wandering on the road, completely naked. She does not remember much, but she recognized Charlie's house as they drove past it and it made her feel safe. Bruce rushes off to a dinner engagement, leaving a sleep-deprived George to cope with the delirious woman. The next morning, George awakens to her screams. She recalls that she is Charlie, reincarnated as a woman. After getting over the shock, she convinces George of her identity by telling him about a dirty trick that she had recently played on him as a man. George realizes that this must be a case of karmic retribution for all of the women that Charlie had used and betrayed.
All manner of complications arise as Charlie decides to take advantage of the situation. George helps her by establishing her as Charlie's widow, figuring out their finances—they are both broke—and boosting her morale. From the beginning, Charlie finds herself subject to a whole new set of emotions and sensations. Her masculine mannerisms begin to fade, partly because Charlie is a consummate actor, but also because the change is more than skin deep. At one point, she bursts into uncontrollable tears. George comforts her as he would a weeping girl, wiping her tears and stroking her hair to calm her, then pulls back, disturbed at the tenderness.
Although Charlie has changed her gender, she is unable to change her ways. She decides to solve her money problems by using her intimate knowledge for blackmail and by marrying Bruce for money. The plans fall apart when Bruce, on the verge of passing out, reveals the depth of his love for her. Charlie takes pity on him and slips the engagement ring into his hand.
Eventually, in a grim role-reversal that she recognizes when it happens, Charlie is chased around the house by Leopold, who cheerfully spouts amorous nonsense and is intent on making love to her. Rusty arrives, gun in hand, and, just as Charlie climbs onto the terrace railing with intent to jump, Rusty shoots her, and she plunges into the ocean below. George, who has arrived in the midst of the melee, leaps after Charlie, but there is no sign of a body. After admonishing the Sartoris for their actions, George orders them to leave and never tell anyone about it. The couple reconcile, and Leopold promises eternal gratitude to George.
George is asleep in a chair; the sound of a woman's voice repeatedly calling "Charlie" wakes him. This time, there are two beings on the terrace: a woman and her Great Dane Charlie. George quickly establishes that she is a real person, Virginia Mason. She takes a look at him and decides that he needs food. She commands Charlie to sit and stay. Virginia and George talk in the kitchen; it is clearly love at first sight. The dog goes into the living room, to the bookcase, to Charlie's secret cache of vodka (behind War and Peace). The bottle falls and breaks; Charlie laps a bit from the floor and, looking heavenward, begins to howl.
