On 16 September, Gautham Krishna, Prakash Raj, a superstar, is getting ready for the release of his new film. Traffic Constable Satyamoorthy, Cheran, returns to duty after his suspension for taking bribes. Dr. Robin Joseph, Prasanna, a cardiologist, is celebrating his first wedding anniversary. Karthik Vishwanathan, Sachin Mani, an aspiring TV journalist, starts his first job with an interview with Gautham. At a crowded traffic junction, Karthik, who was set to interview Gautham, and Ajmal, Mithun Maheshwaran, traveling on a bike, are hit by a speeding car and rushed to Global Hospital. Also at the junction, in another car, was Robin. Karthik goes into a coma and is declared brain dead, although he is kept alive on a ventilator.
Meanwhile, Gautham's ailing daughter Ria, Gabriella Charlton, whose heart condition worsens, urgently needs a heart transplant. At first, Karthik's parents do not agree to donate their son's heart, but Ajmal and Karthik's girlfriend Aditi, Parvathy Thiruvothu, persuade them. Now that the heart is available, the problem is how to transport it to Vellore. No chartered flights or helicopters were available, and so the heart must be taken by road. Someone had to drive 150 kilometers in under two hours during rush hour.
City Police Commissioner Sundarapandian IPS is asked to carry out the mission. He initially refuses, considering the complexity and risk involved, but finally succumbs to the persuasion of Dr. Arumainayagam. Satyamoorthy agrees to do the mission, as he had the experience of chauffeuring the Chief Minister's convoy, and he starts the mission in a Ford Endeavour. Accompanying him on the mission are Robin and Ajmal. At some point, they lose connection, and the vehicle mysteriously disappears. Under pressure and stress, Satyamoorthy trusts his own instincts and takes his own route. Pandian loses patience and hope that he will be able to transport the heart in time, resulting in cancelling the mission. Just in time, Satyamoorthy manages to get connection, which motivates everyone to deliver the heart safely in time.
As the mission proceeds, it is discovered that before Robin committed to accompany Satyamoorthy on this mission, he had attempted to kill his wife Swetha due to her affair with his best friend. To escape from the police, Robin tries to sabotage the mission, but Gautham's wife convinces him to save her daughter's life. They reach the hospital in time to save Ria's life just as Karthik's father Jayaprakash and mother Lakshmi Ramakrishnan prepare to cremate their son.
