Young Alfred 'Al' Yankovic, Weird Al Yankovic, discovers a talent for turning popular songs into playful parodies while facing his father’s stern disapproval. His mother, Mary Steenburgen, secretly buys him an accordion, but his father, Gary Cole, destroys it after catching him at a forbidden polka party, a moment that strains their relationship and plants the seeds of his artistic rebellion.
Years later, a grown Al shares a cramped apartment with Steve, Jim, and Bermuda, and he keeps getting rejected at band auditions as an accordionist. While he sips a bologna sandwich and hears My Sharona on the radio, a spark lights up: he writes the cheeky tune My Bologna and sends it to a local radio DJ, who airs it immediately. He then heads to Scotti Brothers Records, where the brothers mock him but hint they might reconsider if he gains more experience.
A pivotal moment comes when Al performs I Love Rocky Road at a biker bar, with his roommates stepping in to flesh out the act; the performance captures the attention of Dr. Demento, Patton Oswalt, who offers to manage him and suggests adopting the stage name "Weird Al." At a party hosted by Dr. Demento, the mood sharpens as Wolfman Jack dares Al to parody Queen’s Another One Bites the Dust with a cameo by John Deacon. Al rises to the challenge with Another One Rides the Bus, a stunt that sets off a whirlwind of celebrity buzz and helps him land a record contract. His debut album explodes in popularity, a phenomenon affectionately known as the “Yankovic bump,” and he even garners praise from unlikely fans like Oprah.
Back home, Al calls his parents only to hear their lingering skepticism. Dr. Demento pushes him toward writing an original song, but Al initially resists. A wild detour occurs when Demento hands him guacamole laced with LSD, a moment that spurs the creation of Eat It. Madonna, seeking the famed “Yankovic bump,” begins a romance with Al to coax a parody of her hit Like a Virgin, though he remains convinced that he now only writes original material. Their romance alarms Dr. Demento and the band, but the couple carries on. Just before a major show, Al learns that Michael Jackson has riffed on Eat It with a parody of Beat It, a development that fuels his frustration and fear of misinterpretation.
An inebriated Al endures a near-fatal car crash and, after regaining consciousness in the hospital, unveils Like a Surgeon with a dramatic onstage premiere that same night. Yet, as Eat It looms as the finale, he becomes enmeshed in a chaotic moment, drinks too much, berates the crowd, and lands in jail for lewdness. Upon his release, he opens up to Madonna about his fear of losing the people who matter, sensing that she may be the last one left.
Madonna is then drawn into a high-stakes kidnapping by Pablo Escobar’s agents, who are eager fans ready to bend his success to their ends. Al travels to Colombia to intervene, breaking into Escobar’s compound and refusing to perform. A violent confrontation ensues, and Al ends Escobar’s operation in a desperate showdown to save Madonna. Yet Madonna’s plans do not end there; she presses him to retire from music and help seize the drug empire, an offer he rejects.
Returning home, Al is drawn back to his father’s factory floor, where his father confesses that he always supported his son’s path, even as he hid a revealing truth: he grew up in an Amish community and was excommunicated for playing the accordion, a past that shaped his caution about Al’s future. With new resolve, Al presents his father’s song, Amish Paradise, on a grand stage and earns a major award in 1985. The triumph is cut short when he is assassinated onstage by one of Madonna’s henchmen, a brutal twist that shatters the dream.
In the aftermath, Madonna visits Al’s grave, only to be grabbed by his undead arm, a final eerie note that lingers as the memory of his extraordinary, boundary-pushing career endures.