After Quentin Beck (played by Jake Gyllenhaal) frames Peter Parker (portrayed by Tom Holland) for murder and discloses his Spider-Man identity, the lives of Peter, his girlfriend Michelle "MJ" Jones-Watson (Zendaya), best friend Ned Leeds (Jacob Batalon), and Aunt May (Marisa Tomei) become entangled in a web of chaos. They face intense scrutiny as the Department of Damage Control interrogates them. Meanwhile, Quentin is celebrated as a heroic figure who sacrificed himself for the greater good.
Following a breakup with Happy Hogan (Jon Favreau), J. Jonah Jameson (J.K. Simmons) spearheads a public backlash against Spider-Man, painting a negative portrait of him. Peter attempts to clarify the situation to the DODC, but he learns that Nick Fury (who was supposed to back him) has been off-planet for a year. Fortunately, lawyer Matt Murdock (Charlie Cox) helps to have the charges dropped, yet the group continues to face backlash from the public and media.
As they seek refuge from the relentless press, Peter and May move into Happy's apartment. The world seems split between supporters and critics of Spider-Man, while Eugene (Tony Revolori) tries to exploit the situation by claiming a close relationship with Peter—with a book to boot. When Peter, MJ, and Ned's applications to MIT are denied, it’s clear that their association with Spider-Man has affected their chances. Desperate, Peter turns to Stephen Strange (Benedict Cumberbatch) at the New York Sanctum, asking for a spell to make the world forget he’s Spider-Man.
Strange proposes a risky spell, which takes a turn for the worse when Peter insists on adjustments to ensure MJ, Ned, and May remember him. Strange manages to halt the spell, but the damage is done—some individuals from other dimensions who know Spider-Man’s identity have been summoned. He orders Peter, MJ, and Ned to track them down, giving Parker a special bracelet to capture them.
They soon successfully find Max Dillon (Jamie Foxx) and Flint Marko ([Thomas Haden Church]) but encounter trouble when Norman Osborn ([Willem Dafoe]) arrives, tormented by his ‘Green Goblin’ alter ego. Together, with the likes of Otto Octavius (Alfred Molina) and Curt Connors ([Rhys Ifans]), they debate their grim fates—having been pulled from their universes just before their deaths. While Strange plans to return them, Peter argues for curing them first to prevent their demise.
In a daring move, Peter steals the spell and locks Strange in the Mirror Dimension. He takes the villains to Happy's apartment where he attempts to cure them, but chaos ensues when Goblin leads the others to betray Peter and fatally wounds May. In her dying moments, she imparts the wisdom that with great power comes great responsibility, pushing Peter into a deeper commitment to his role as Spider-Man.
As Peter struggles with his anguish, Ned discovers he can create portals using Strange’s ring and unintentionally summons alternate versions of Spider-Man—Peter-Two ([Tobey Maguire]) and Peter-Three ([Andrew Garfield]). Together, they rally to support Peter-One in his quest to confront the villains. They devise a plan to draw the villains to the Statue of Liberty, where the team works together to cure them, bringing Osborn back from his destructive tendencies.
However, the situation escalates dramatically when Goblin unleashes a new spell, threatening to fracture the multiverse. In the heat of the battle, Peter-One realizes the only way to protect everyone is to erase his own existence from everyone’s memories. After pledging to one day reconnect with MJ and Ned, the spell is cast, and everyone returns to their respective realities—including a piece of the Venom Symbiote left behind after a brief crossover with Eddie Brock ([Tom Hardy]).
Two weeks later, Peter, still haunted by his loss, considers reaching out to MJ and Ned but ultimately decides against it. In a moment of reflection at May’s grave, he finds inspiration in her memory. With a new suit in the works, he resolves to rise once again as Spider-Man, committed to his path of duty.
