The story begins with Jibran (Kumail Nanjiani) and Leilani (Issa Rae), who wake up following a night filled with passion, slowly revealing the tender bond that has formed between them. Fast forward four years, and their relationship has devolved into a cycle of incessant bickering, where their minor disagreements rise to comical proportions. The tension reaches a boiling point at a dinner party for friends Bobby (Jaren Mitchell) and Reya, culminating in a dramatic confrontation that leads them to realize their relationship might be at a dead end.
However, just after this poignant realization, chaos interrupts as a mysterious cyclist (Nicholas X. Parsons) crashes into their vehicle, leaving them shaken. Leilani seizes the moment to grab the cyclist's phone, but before she knows it, a self-proclaimed officer, Mustache (Paul Sparks), hijacks their car, leading them on a wild chase that spirals into violence in a dark alley. The gravity of the situation becomes clear as the cyclist is found dead, revealing the seriousness of their predicament.
Stunned by the brutality, they are further rattled by a hipster couple who unwittingly crosses their path. As law enforcement is summoned, Detective Martin (Andrene Ward-Hammond) begins to close in on them, forcing the couple to concoct a plausible alibi over milkshakes. This effort, however, quickly falls apart when Leilani's phone meets an unfortunate fate, leaving them vulnerable to suspicion.
In a desperate bid to clear their names, Leilani proposes that they investigate the incident themselves, tracing their first lead back to an enigmatic figure named Edie (Anna Camp), who summons them to the infamous Dragon's Den club. Upon their arrival, they're met by Edie on the balcony, who is suspicious of their intentions and believes they are tangled in a larger conspiracy related to her husband Brett (Kyle Bornheimer). Clinging to incriminating evidence, she ties them up in her own home and presents them with a terrifying choice: suffer a bath in scalding bacon grease or face whatever horrors lurk behind the barn door.
Jibran chooses the latter, only to be welcomed by a horse's kick that sends him reeling. Meanwhile, Leilani opts for the grease, but as tensions boil, she cleverly turns the tables on Edie, dumping the hot grease on Brett, allowing Jibran to fight back. In the chaos, they escape, driven by a relentless need to uncover the truth.
Their journey takes them to a local store to change their outfits, now stained with evidence of their encounter. Reminiscing about their earlier disastrous date, they realize that a clue found during their escape—a slip of paper—could lead them closer to understanding the events of the night. This revelation brings them to a lively fraternity house, where they learn about a shady scheme involving Bicycle and a group of rowdy boys.
As they gather information, they are confronted by the enigmatic "Mustache," who begins taking out the attendees one by one, causing Jibran and Leilani to hide in fear. Amidst this newfound danger, they manage to escape with an envelope containing vital photos before being apprehended by police.
Detained and interrogated, Jibran and Leilani bear their souls, which inadvertently leads to their exoneration due to traffic camera footage. To their surprise, they learn that their actions contributed significantly to dismantling the Sanctarium cult's criminal activities.
Their tumultuous journey does not end there; they find themselves ensnared once more by Mustache, who reveals his duplicitous ties to the cult. Tied up and taken to the docks for what looks like a fatal end, Leilani's quick thinking allows her to turn the situation around, ultimately delivering a blow that sends Mustache plunging into the water just as law enforcement arrives.
Recovering from their harrowing ordeal, they share an unexpected moment of intimacy in an ambulance, and one year later, embark on a new adventure to participate in "The Amazing Race." Yet, the prospect of facing unexpected challenges, including one involving a horse, brings back memories of their previous chaotic escapades.
