The Four Skulls of Jonathan Drake

A brilliant yet unscrupulous physician-scientist who blends medicine with occult practices to prolong life. He is the mastermind behind the head-shrinking experiment and the Drake curse, manipulating others to obtain the skulls needed to complete the ritual. His calculated ruthlessness makes him the central antagonist, willing to kill to secure his own immortality.

The elder Drake brother and patriarchal figure, whose death at 60 sets off the investigation into the family curse. His passing reveals the mysterious link between the Drake men and the curse that haunts the crypt. His demise acts as the inciting incident that pulls the other characters into the mystery.

Jonathan's daughter, intelligent and brave, she becomes a key investigator of the skulls and the curse. She helps uncover the Prints containing skull images and decodes the Cult of Headless Men. She is captured by Zurich and ultimately a crucial ally in ending the curse.

A skeptical police officer who investigates Kenneth's death and the cryptic skull symbolism. He believes in rational explanations but gradually collaborates with Alison to confront Zurich's occult scheme. He plays a pivotal role in the final confrontation.

A professor who first senses the skull visions and is the central figure trying to end the curse. He devises a plan to sacrifice himself to release his soul from the skull, but ultimately actively participates in defeating Zurich and saving his family.

Jonathan's physician friend who investigates the cause of the unusual deaths and reveals the curare in Jonathan's blood. He becomes a victim of Zurich's experiments when the villain displays his head; his head is used as proof of the mystic plot.

A Jivaro witch doctor who serves as the occult enforcer in Zurich's plan. He attacks Jonathan and helps trigger the climactic confrontation, but dies in a confrontation with fire. He represents the supernatural element fueling the curse.