After a night of debauchery, five military comrades (Mat Best, Nick Palmisciano, Jarred Taylor, Jack Mandaville, and Vincent “Rocco” Vargas) wake up in a drunk tank and discover that while they were passed out, the world outside has fallen into a zombie apocalypse. A zombified Richard Chindler, William Shatner, lunges at Rocco, but Rocco sinks the blow with a decisive head hit, ending the threat in that moment. Rather than panic, the group feels oddly thrilled by the chaos unfolding around them, a stark contrast to what one might expect in such a scenario.
As they move through the city, they kill the zombified transgender woman and witness Marcus Luttrell, Marcus Luttrell in danger as zombies close in. The crew steels themselves and arms up with batons stolen from the police station they were held in, turning a moment of confusion into a chance to defend their lives. Along the way, they encounter a mortally wounded soldier who urges them to reach Range 15, though his warning is cut short as he begins to transform into a zombie, nearly biting Jack Mandaville before Mat intervenes and ends the threat with a well-placed baton strike.
After a string of run-ins with the undead, the team reaches a police armory where Heather and Eliza have taken shelter, and Evan Hafer is cuffed to a chair for not sharing weapons. The group studies a map and learns that Range 15 is an ELE — an Extinction-Level Event — fallback point. With rifles and sidearms recovered, the five-soldier unit, now joined by Heather and Eliza, pushes toward Range 15.
For transport, they head to the impound lot and decide to take Jarred’s seized whiskey truck to move their supplies. Before departure, a brutal moment unfolds as Evan is attacked by a zombie; Mat intervenes and ends the threat. On the road, they face another flood of zombies and discover that a bad batch of distilled whiskey, mixed with an unknown component, can act as a cure. When Rocco tries to use a bottle as a Molotov, it backfires and instead reverts infected people back to normal. Realizing the potential, Nick suggests taking the cure to Colonel Holloway, Keith David, to study and distribute it.
Holloway dispatches his top man to Range 15 to oversee testing. The group encounters Sergeant Major Gene Vandenham, a cocky Army Special Forces officer whom Mat dislikes for his ego, and Vandenham warns that the zombies are becoming faster and stronger. Holloway arranges for helicopter transport to avoid the roads, but before they can leave, Pilot Grigsby, Sean Astin, reveals he is infected and chooses to jump from the helicopter, sacrificing himself. The group continues on foot toward Range 15, though Mat is bitten in the leg during a later zombie attack. To accelerate the cure’s absorption, Nick and Rocco propose delivering the whiskey directly into the bloodstream, an idea that leads them to pursue a more direct route to Range 15.
Mat is eventually presumed dead but reappears at Range 15, telling the team he was saved by a legendary group known as the Zombie Slaying Dream Team — Leroy Petry, Clint Romesha, Tim Kennedy, and Tom Amenta. 2LT Chandler radios that the zombies are breaching the defenses, forcing the survivors to prepare for a final stand. A fierce clash follows, including a dramatic moment where Tim Kennedy faces off against “Zombie Couture” (Randy Couture) and emerges victorious. The group also confronts Danny Trejo in a brutal melee, and Mat eventually slashes Trejo’s zombified form to end the threat.
Back at Holloway, the president is prepared to honor the saviors, and the ceremony seems poised to recognize Mat and his team. However, the president is actually praising Sergeant Major Gene Vandenham, a twist that leaves Mat frustrated and briefly overshadowed by the swaggering officer. In the final scene, [Rocco] returns to a gas station they had stopped at earlier, where he is reunited with a zombie he once fell in love with. The two share a kiss before he carries her into the fading sunset, closing the story on a moment both eerie and oddly hopeful.