Inspector Zenigata, Gorô Naya travels to Castle Dracula in Transylvania to confirm the fateful death of his longtime nemesis, Arsène Lupin III. The scene is staged with a decoy body, a ruse Lupin exploits to slip away from the castle’s grip. The chase then pushes Zenigata onward, across continents, chasing whispers of Lupin’s next move while Lupin and his partners—Kiyoshi Kobayashi as Daisuke Jigen and Makio Inoue as Goemon Ishikawa XIII—plot a bigger score. Their destination is the wild promise of immortality, a prize tied to a legendary artifact known as the Philosopher's Stone.
Lupin’s instinct for risk leads him and Fujiko Mine, Eiko Masuyama in tow, to a desert of possibilities in Egypt, where old secrets and new betrayals collide. Lupin believes the Stone will resurface in the Giza Necropolis, and his team hurries to beat a clock that ticks toward peril. Fujiko, driven by her own ambiguous loyalties, has already entangled herself with a mysterious client and steals the Stone from Lupin in Paris, setting in motion a chain of events that neither Lupin nor his rivals fully predict. The benefactor behind this tangled web—Kō Nishimura as Mamo—discovers the Stone is a fake, a clever deception Lupin himself engineered, and uses that discovery to tighten his hold on the trio.
When Mamo moves, his forces strike first. Lupin, Fujiko, Jigen, and Goemon are routed from their hideout as Flinch, Shozo Iizuka, closes in, and the group finds itself scattered, hunted by powerful enemies who want to control their talents for themselves. The ensuing blame game strains the crew: Jigen and Goemon suspect Fujiko, while Lupin tries to hold the fragile thread of trust. Lupin promises to temper his own desires for Fujiko’s sake, but her reappearance soon shatters the vow and pulls them toward a new orbit of danger. With nowhere safe, the troupe travels toward the sea, only to stumble upon a seemingly abandoned house that offers food and water—but also the next test of loyalty when Fujiko returns, wounded, forcing Lupin to break the promise that kept his crew together.
Flinch arrives to take Lupin and Fujiko to Mamo, and the drama intensifies as Jigen and Goemon race to decipher clues while being questioned by American agents. The agents’ interrogation ends without a conviction, but the snippets of information are enough to steer Jigen and Goemon toward a Caribbean island where Mamo’s lair lies. There, Mamo—who presents himself as a suave, omniscient patron and officially known as Howard Lockewood—tells Lupin that the whole arc was a test of his skill and his heart. He offers the possibility of immortality for Lupin and Fujiko, but Lupin’s ambitions remain focused on the Stone itself, a reminder that for him, some prizes are worth more than endless life.
A chase ensues across Mamo’s fortress and across the sky as the USAF bombards the base. Jigen rescues Lupin and Fujiko in a dramatic turn, and a tense duel on the island with Flinch tests Goemon, who loses his legendary sword, the Zantetsuken, in the process and leaves for training to recover its edge. Zenigata remains hot on Lupin’s trail, and his pursuit culminates in a dramatic turn when the ICPO chief travels to Colombia to tell him that he is off the Lupin case—an admission that leaves Zenigata to resign and chase Lupin as a private citizen, driven by a stubborn sense of duty.
On the Colombian leg of the journey, Mamo reveals the staggering truth: his ten-thousand-year lifespan has been possible only through cloning, and Lupin himself has been among his “experiments.” The confession spirals into a mind-bending vision in which Mamo discloses his uncanny history, and Lupin learns that the man behind his career has been cloning himself to seed conflicts across eras. Mamo steps from illusion into action, reclaiming Fujiko by force and setting in motion a plan that would repopulate the Earth through a calculated nuclear threat. Lupin, realigning his priorities, confronts the mastermind with cunning and resolve.
In a temple chamber, Mamo presses Fujiko to embrace a future that hinges on destruction, proposing a dangerous kind of immortality that would erase the line between creator and creation. Fujiko refuses to abandon Lupin, a moment that crystallizes the core of their unstable alliance. Lupin proactively rigs the missiles to explode before launch, thwarting Mamo’s monstrous design, while the tyrant presses forward with a final attack on Lupin. In a desperate clash of laser and steel, Lupin uses the tip of Goemon’s sword, entrusted to him earlier, to deflect the lasers and scorch the mastermind’s ambitions.
A rocket rises, revealing a colossal brain—the original Mamo—contained within. Lupin realizes that the clones are but a mirage of the real menace, and as the rocket ascends, he secures an explosive device to prevent a catastrophe. The glass shatters, and Mamo’s brain drifts toward the sun, finally rendering his centuries-long scheme moot. Lupin and Fujiko emerge from the wreckage, only to be captured by Zenigata, who has finally closed the net but must confront the ambivalence of loyalty, duty, and love in these high-stakes games. Fujiko’s rescue by Kiyoshi Kobayashi in a broader sense of alliance marks a temporary win for the lovers’ uneasy partnership, while Lupin and Zenigata trade a stubborn stalemate that ends with both men continuing their chase—Lupin as a fugitive, Zenigata as a man who cannot quit.
In the last motion, Goemon—standing atop a mountain—delivers a closing line that shatters the fourth wall, signaling that this ever-evolving dance between thief and lawman will echo across time. The story preserves the pulse of a heist saga that loves its own mythos: the thrill of a plan that nearly works, the sting of betrayal, and the spark of romance that makes Lupin’s world feel at once dangerous and alive. From Dracula’s castle to the sunlit ruins of Colombia, the saga threads together legend, loyalty, and a sense that some wishes—like immortality—are best left unresolved, while the real treasure remains the endlessly shifting partnership between Lupin, Fujiko, Jigen, and Goemon—and the relentless chase that keeps them all in motion.
