Eva Eloísa Maturén is on her way out of town when her car breaks down on the side of the road. She makes it into a small town, and when she asks for directions to a hotel, the mechanic points her to Margot Elba Escobar's place. Margot owns a small hotel, and every year some of her friends come to celebrate Liz's birthday. She usually would not accommodate another guest during this time, but seems to take pity on Eva and lets her stay. Unbeknownst to Eva, Margot and all of her friends at the hotel this week are lesbians. Having just recently lost a young child to cancer and finding out her husband may possibly be cheating, she seems to have a lot on her mind when she arrives.
Liz [Patricia Velásquez] takes a liking to her after Eva sabotages her fishing outing and invites her to dinner with her friends that night. When her friends see her, Liz bets one of them that she can have Eva in her bed within three days. At dinner, Eva discovers that these women all have something in common: they are lesbians. Almost all of them have had or are currently in relationships with one another, and some have kids from previous heterosexual relationships. This surprises Eva, hinting at limited interaction with homosexual people and suggesting she may have been heterosexual for most of her life.
Eva seems to be more open-minded than most people to the women's situation. They explain that they reside outside of town in order to escape the wary looks and slander from those in town. As relationships are being formed, an even deeper connection grows between Eva and Liz. Part of this is because Liz makes a bet with one of the other women that she can get Eva in bed with her within three days. Although this was Liz's initial motivation for getting close to Eva, it becomes clear that true feelings begin to replace the bet.
As they go on different adventures, Liz's secret—one she has kept from everyone except for Dolores [Mimí Lazo], with whom she had a very intimate relationship—is revealed, and it takes a toll on everyone involved: her cancer is back. Coincidentally, it was the same illness that Tommy, Eva's son, had when he died. On the night of Liz's 37th birthday celebration, she collapses and is rushed to the hospital, learning that she has only a couple of months to live. While trying to cope with her fear of not having left a lasting mark, she spends her time surrounded by her friends.
