Alexandra Medford, Jane Spofford, and Sukie Ridgemont are three discontented women residing in the charming town of Eastwick, Rhode Island. Alex, a sculptor, navigates life as a single mother, while Jane, a recently divorced music teacher, grapples with her inability to conceive. Sukie, a columnist for the local newspaper Eastwick Word, balances her life with six kids. Each of them has faced the hardships of lost relationships; Alex's husband has passed away, Jane's has left her, and Sukie's has walked out. Unbeknownst to them, they form a coven, convening weekly to share their thoughts on their ideal partners.
When a mysterious man acquires the town's iconic Lenox Mansion, his presence piques the interest of the entire town, save for Felicia Alden, the devout spouse of newspaper editor Clyde Alden, who also happens to be Sukie's boss. She instinctively senses that the newcomers’ intentions are sinister.
During a recital hosted by Jane, this enigmatic figure makes a memorable entrance, stirring up gossip. As Sukie receives flowers from him, she remembers his name—Daryl Van Horne. The excitement escalates when Sukie's pearl necklace breaks, sending beads scattering and causing Felicia, who had earlier mocked Daryl’s name, to tumble down the stairs, resulting in a broken leg.
In an unexpected twist of fate, Daryl’s seductive charm intrigues Alex the next day; although he initially offends her with his remarks, she finds herself manipulated into compliance after attempting to leave. Later, during a calm conversation, he captures the attention of the reserved Jane, leading to a wild and passionate duet on the cello that ends in flames, leaving Jane utterly enthralled.
Daryl's charm soon attracts all three women, igniting feelings of jealousy and rivalry among them. To their astonishment, they discover their shared magical abilities when they accidentally levitate a tennis ball. As they embrace their newfound powers, they decide to share Daryl, but the townspeople, incited by Felicia's rumors, begin to ostracize them. When the women’s loyalty falters, Daryl leads them into a dark spell directed at Felicia, who, after a violent episode, meets her demise at the hands of her husband in a fit of rage.
Following Felicia's untimely death, the trio opts for separation to regain control over their chaotic powers. Heartbroken over their abandonment, Daryl exploits their deepest fears: Alex envisions herself surrounded by snakes, Jane experiences rapid aging, and Sukie endures unbearable pain. Recognizing that only through witchcraft can they rid themselves of Daryl, they agree to feign reconciliation.
The following morning, with Daryl distracted, Alex crafts a voodoo doll using his hair and wax, hoping to weaken his hold on them. To their astonishment, as they perform acts of harm to the doll, Daryl feels each impact, leading him to a church filled with worshippers where he, overcome with rage, curses the witches before, astonishingly, regurgitating cherry pits, just like Felicia.
In a frenzy, Daryl storms back to exact revenge on the witches, but as they attempt to act nonchalantly, he shows up disheveled and furious. His fury drives the situation further into chaos, ultimately breaking the doll and transforming Daryl into a colossal monster. In their desperate bid for survival, the witches toss the doll into a fire, diminishing Daryl to a shriveled homunculus before he vanishes entirely.
Eighteen months later, the women share a reformed life in Daryl’s mansion, each with a bouncing baby boy. As the children play, Daryl re-emerges, this time on a wall of television screens, beckoning them to "give Daddy a kiss." However, the united women swiftly shut off the screens, preventing Daryl from reclaiming any shred of his past power.
