Amy Mitchell, portrayed by Mila Kunis, juggles her responsibilities as a married mother of two, Jane (Oona Laurence) and Dylan (Emjay Anthony). Overwhelmed by her commitments, Amy dedicates her energy to a fast-paced sales job at a trendy coffee company, meticulously prepares healthy lunches for her children, and actively participates in their school’s Parent-Teacher Association (PTA), which is led by the overbearing Gwendolyn James (Christina Applegate) alongside her friends Stacy (Jada Pinkett Smith) and Vicky (Annie Mumolo).
When Amy discovers her husband Mike (David Walton) cheating on her with a nude hooker online, she decides to throw him out and attempts to maintain some semblance of balance in her life. After a particularly taxing day, Amy confronts Gwendolyn's excessive bake sale plans and makes the bold decision to quit the PTA publicly. At a bar, she meets Carla (Kathryn Hahn), a free-spirited single mom, and Kiki (Kristen Bell), a stay-at-home mom who is envious of Amy's boldness.
Their friendship soon reveals the underlying struggles each faces: Kiki contends with a domineering husband who places all childcare duties on her, while Amy and Kiki are taken aback by Carla's laissez-faire parenting style. The three moms embark on a wild night out, igniting Amy's desire to relax with her children—she takes them for joyrides in Mike's classic car, indulges them with Arby's, and encourages Dylan to develop independence by not catering to his every whim. Furthermore, Amy treats stressed-out Jane to a delightful spa day.
However, when Amy introduces store-bought doughnut holes for Gwendolyn's bake sale, Gwendolyn retaliates by having Jane removed from the soccer team. Fueled by anger, Amy decides to challenge Gwendolyn for the position of PTA president. Although Amy's initial meet-and-greet at her home draws minimal interest, the other moms quickly abandon Gwendolyn's pretentious gathering after realizing it's set to be an evening of lectures. Consequently, Amy enjoys a successful, raucous party at her place.
In desperation, Gwendolyn resorts to malicious tactics by framing Jane with drugs, which leads to her suspension from all extracurricular activities coinciding with Amy's job loss. Both Jane and Dylan choose to stay with Mike, who offers an amicable divorce as they perceive their mother’s struggles as failures. Amidst all of this, Amy finds herself without a job, with her younger boss failing to empathize with her situation.
However, a wave of determination ignites within Amy due to the support of Carla and Kiki, who finally steps up to her husband. At the PTA election, Amy gives an inspiring speech about the challenges faced by moms everywhere, advocating for the need to unwind, lessen stress, and accept imperfections. Triumphing in the election, she ends up comforting Gwendolyn, who reveals that her insistence on controlling the PTA stemmed from her own frustrations over her husband's scandals.
Weeks later, Amy's advocacy results in a more balanced life for everyone: Jane experiences less stress, Dylan shows more initiative, Kiki demands shared responsibilities from her husband, and Carla becomes more engaged as a parent. Amy herself finds new employment with improved pay after her boss recognizes her value, and she continues to connect with Jessie (Jay Hernandez), a charming widower she met earlier. Even Gwendolyn begrudgingly acknowledges the merit in Amy's methods and invites her, Carla, and Kiki for a luxurious day aboard her husband’s private jet.
As the credits roll, viewers are treated to interviews of the cast with their real-life mothers, offering a heartfelt conclusion to this relatable journey.
