On the night of Esteban's 17th birthday, a sudden tragedy upends the life of a devoted nurse named Manuela. While Esteban pursues his favorite actress, Huma Rojo, after a performance of A Streetcar Named Desire in which she plays Blanche DuBois, a car strike changes everything: Manuela allows Esteban's heart to be transplanted to a recipient in A Coruña, setting off a chain of choices that redefine her future. After locating the transplant recipient, she resigns from her job and travels to Barcelona, driven by a secret she has kept from her son—Lola, a transgender woman who would be Esteban's other mother.
In Barcelona, Manuela’s quest leads her to an old circle of friends and new bonds. She reconnects with Agrado, a warm and witty transgender sex worker, and gradually becomes entwined with Huma and her co-star Nina Cruz, who is wrestling with heroin addiction, as well as Rosa, a young HIV-positive nun who works in a shelter for battered sex workers and is pregnant with Lola’s child. Manuela’s life becomes a tapestry of care and duty: she tends to Rosa during her pregnancy, serves as Huma’s personal assistant, and steps in as Nina’s understudy during a drug-induced crisis.
Along the journey, Rosa asks a taxi to stop at a park, where she meets a stark contrast of recognitions. She spots her father’s dog Sapic and then faces her father, who suffers from Alzheimer’s and cannot recognize her, while Sapic alone seems to recognize Rosa. Rosa’s life ends tragically as she dies giving birth to a healthy boy, and at her funeral, Manuela is drawn into Lola’s presence again. Lola—who has lived as Esteban’s other parent—reveals that she is dying from AIDS and confesses a lifelong longing to have a son. Manuela shares the story of their son Esteban and his fatal accident, linking the past to Lola’s fading future.
Manuela’s act of love continues as she adopts Rosa’s son, caring for him at Rosa’s parents’ house. The household becomes tense and complex: the father does not understand who Manuela is, and Rosa’s mother introduces her as the new cook living there with her grandson. A quiet, careful exchange occurs as Manuela presents Lola with a photograph of their shared son, a moment that Lola absorbs with a bittersweet mix of memory and grief. Rosa’s mother confronts the reality of Lola’s connection to the child, fearing contagion and moral judgment, and the atmosphere heats with fear and tension as Lola’s past and Manuela’s secret collide.
Unable to stay at Rosa’s house, Manuela flees back to Madrid with Esteban and writes a heartfelt letter to Huma and Agrado, apologizing once again for not saying goodbye in the way she had once done years earlier. Time passes, and two years later, Manuela returns to Barcelona with Esteban, who remains healthy and AIDS-free. At an AIDS convention, she reunites with Huma and Agrado, who now run a stage show together, and informs them that she plans to stay with Esteban’s grandparents. When she asks about Nina, Agrado reveals that Nina left Huma, returned to her hometown, got married, and now has a son of her own.
This story, threaded with loss, resilience, and the precarious ties of chosen family, centers on a mother’s fierce devotion and the unexpected ways love can rewrite a life. Throughout Manuela’s journey, the echo of Esteban’s death and Lola’s struggle against a terminal illness hover in the background, shaping every choice she makes as she moves between Madrid, Barcelona, and the people who become part of her improvised, improvised, but deeply human family.
