The film opens in 2017, centering on four elderly best friends: [Lou](lily-tomlin), [Trish](jane-fonda), [Maura](rita-moreno), and [Betty](sally-field). They gather to watch a thrilling football game between the Pittsburgh Steelers and the New England Patriots, the latter being their favorite team. The friends participate in a lively superstition, which they believe contributes to the Patriots' victory, involving Betty stepping on a ladder, Trish reading a magazine, Maura sipping tea, and Lou knocking over a bowl of chips. Their rituals work, sending the Pats to the Super Bowl, where they cheer excitedly for their star quarterback, Tom Brady.
[Trish](jane-fonda) is celebrated for her past as an erotica novelist focused on Rob Gronkowski and also for her stint as a mascot in advertisements during her youth. [Betty](sally-field) excels in math and is married to the somewhat scatterbrained [Mark](bob-balaban). [Maura](rita-moreno) has moved to a retirement home following her husband's death, even though he left their house to her. Meanwhile, [Lou](lily-tomlin) has been cancer-free for 16 years. The friends learn about a contest from their favorite Patriots radio show, offering tickets to Super Bowl LI, and they immediately decide to enter. [Maura](rita-moreno) seeks help from her friend [Mickey](glynn-turman) at the retirement home, who seems to have a crush on her, while [Lou](lily-tomlin) shares a heartfelt story about how watching football during Brady's rookie season helped her cope with her chemotherapy.
When [Lou](lily-tomlin) announces they’ve won the contest and will be attending the Super Bowl, excitement fills the air. However, [Betty](sally-field) keeps her trip a secret from [Mark](bob-balaban). As they attempt to fetch [Maura](rita-moreno), they find her fast asleep. [Trish](jane-fonda) distracts [Tony](jimmy-o-yang), the manager, allowing [Lou](lily-tomlin) and [Betty](sally-field) to secretly rescue [Maura](rita-moreno).
Arriving in Houston, TX, the ladies check into their hotel, where they must share two beds. [Lou](lily-tomlin) receives a concerning call from her daughter [Sara](sara-gilbert), who reports that doctors have been trying to reach her, but [Lou](lily-tomlin) conceals her true whereabouts.
The next day, they explore the NFL Experience, where [Lou](lily-tomlin) and [Maura](rita-moreno) impress everyone at a football-throwing contest, while [Trish](jane-fonda) captivates a crowd with an impromptu reading of her erotica. She catches the attention of retired player [Dan](harry-hamlin), who shows interest in her. [Betty](sally-field) seizes the opportunity to enter a hot wings contest judged by Guy Fieri, where she triumphs despite the escalating heat. Guy later invites them to a barbecue and a party.
At that night’s party, a woman gifts the ladies some gummies laced with weed unbeknownst to them. As [Betty](sally-field) realizes she misplaced the Super Bowl tickets in her "strap-on" fanny pack, the group frantically searches for a way to obtain new ones. [Lou](lily-tomlin) encounters [Guy](bob-balaban), who returns her fanny pack, while [Maura](rita-moreno) engages in a poker game and shows her skills, leaving the group hopeful for new tickets.
Desperate to find the missing tickets, the ladies learn from [Trish](jane-fonda) about the actual contest winners— a group of men named Tom Brady. They cross paths with a scalper, but can't afford his prices. After another chance encounter with [Guy](bob-balaban), [Betty](sally-field) finally retrieves her lost fanny pack.
As the friends attempt to enter the stadium, they’re confronted by the head security guard [Chip](ron-funches), who reveals the tickets are fake and that they’ve been scammed. Overwhelmed, [Lou](lily-tomlin) confesses she bought them online, fearing it might be her last chance for something unforgettable. Her friends, unwavering in their support, help her find another way to get in.
They meet [Gugu](billy-porter), a poker player who offers to assist them in entering the stadium by disguising them as his dancers. This clever ruse impresses the security guard, allowing them to finally take their seats. While [Dan](harry-hamlin) continues to reach out to [Trish](jane-fonda) through texts, she grapples with her feelings about rushing into a new relationship.
As the game begins, the Patriots struggle against the Atlanta Falcons. The creative ladies find themselves in the coaches' booth, operating controls that enable [Lou](lily-tomlin) to contact Brady directly. She gives a motivational speech about how he inspired her through her treatment, which sparks a remarkable comeback for the team. They ultimately win the championship.
After the game, [Maura](rita-moreno) shares news of her winnings from a bet with a rich opponent, deciding to return to her home, encouraging [Mickey](glynn-turman) to visit her. [Chip](ron-funches) then leads them to meet the Patriots, where [Betty](sally-field) enthusiastically praises Danny Amendola while [Maura](rita-moreno) expresses admiration for Julian Edelman's beard. [Trish](jane-fonda) meets Gronk, who is excited about her book, and [Lou](lily-tomlin) encounters Brady, who thanks her for her inspiration and offers to swap jerseys.
Fast forward to 2020, where [Sara](sara-gilbert) joins [Betty](sally-field), [Trish](jane-fonda), and [Maura](rita-moreno) for another Super Bowl. Initially, it appears that [Lou](lily-tomlin) has passed away, but she surprisingly appears, vibrant and healthy. The four friends gather once more for an unforgettable game.
Before the credits roll, scenes of the four friends relaxing on a beach with Brady are shown, as [Maura](rita-moreno) inquires about his retirement plans. He comments on how challenging it is to think of retirement "when you've still got it," a sentiment the friends wholeheartedly agree with. Finally, a text states that this film is inspired by a true story, showcasing a photograph of the real-life four best friends.
