In the Arctic Ocean near the Helheim Glacier in Greenland, an unfortunate incident unfolds when a surfer rides waves generated by massive ice chunks breaking off due to global warming. As fate would have it, a colossal piece of ice plunges into the water, producing a gigantic wave that tragically overwhelms the surfer, resulting in his drowning. This prompts Captain James Maine (Bruce Davison) of the United States Coast Guard to embark on a mission to investigate the incident in Greenland, accompanied by Dr. Kim Patterson (Brooke Burns). Just as the two arrive, another large chunk of ice plummets into the ocean.
Fast forward to April 10, 2012—exactly 100 years after the RMS Titanic's iconic maiden voyage—the grand unveiling of a new luxury cruise liner reminiscent of the original Titanic takes place. Dubbed the RMS Titanic II, this vessel charts a course retracing the Titanic’s journey, albeit in reverse, sailing from New York City to Southampton. Captain Will Howard (D. C. Douglas) commands the ship, along with the ship's designer, Hayden Walsh (Shane van Dyke), and nurses Amy Maine (Marie Westbrook) and Kelly Wade (Michelle Glavan).
As the ship traverses the Atlantic, a dire message from James Maine alerts the crew about an impending tsunami, indicating that any existing icebergs could be displaced. In the urgent race against time to return to shore, one of the ship's engines sustains damage. Shortly after this, the Titanic II is struck by both the tsunami and a massive iceberg, resulting in significant injuries among the passengers. The impact is catastrophic, with the starboard side of the ship severely compromised and the lifeboat ramps rendered inoperable. In the chaos, Hayden, Amy, and Kelly hastily retreat below decks, where they find Kelly injured. The trio begins their perilous journey towards the upper decks.
Meanwhile, far to the north, an even more formidable tsunami is generated by yet another glacier, causing even more havoc. During the frantic evacuation, the ship's turbines endure immense strain, leading to a catastrophic explosion that takes the lives of numerous passengers and crewmembers, including Captain Will Howard. The explosion ignites a massive fire onboard, and the Titanic II begins to list to the starboard side while sinking at its bow, mirroring the demise of its predecessor.
Desperate for survival, Amy receives a concerning call from her father, warning her about the impending second wave and advising her to avoid the lifeboats, which could easily be swept away. Captain Maine commands the trio to seek refuge in the ship's diving facility. A terrifying turn of events occurs when Kelly is killed by a heavy door, as Hayden and Amy continue to seek safety. After a futile attempt to save a trapped individual behind a jammed door, they finally reach the diving facility, just as the second wave strikes, capsizing the ship and obliterating the lifeboats.
Inside the diving facility, only one oxygen tank and a scuba suit remain. In a selfless act, Hayden offers the scuba gear to Amy, kissing her goodbye while urging her to revive him if he should drown before rescue arrives. Just then, Captain Maine arrives, determined to save Amy and Hayden by swimming through the sinking ship. However, his helicopter runs out of fuel and crashes. Amidst chaos, Dr. Patterson secures a place in a life raft. Eventually, the Titanic II succumbs to the ocean, and despite James's heroic efforts, Amy is left attempting to resuscitate Hayden, only to find it’s too late. Miraculously, she, alongside an unspecified number of injured passengers previously ordered for evacuation by Hayden, is among the few survivors of this tragic maritime disaster.