Class of Nuke ’Em High

An accident at the nearby nuclear plant occurs and is quickly buried by plant owner Mr. Paley to prevent the facility from being shut down. The radioactive water leaks into the town's systems and reaches Tromaville High's drinking fountain. Dewey, a student, is gruesomely killed by the tainted water. The incident sets off mutations and fear at the school.

Shortly after the accident, the Cretins’ behavior grows brutal as the plant runoff mutates them into violent psychopaths. They harvest leaves from the radioactive marijuana plant in the plant yard and sell them to Eddie for $10. The mutated gang casts a looming shadow over Tromaville High as fear spreads.

At Eddie’s indoor bikini beach party that night, he pressures Warren and Chrissy into smoking the radioactive joint. The joint is dropped and trampled before anyone else can try it. The mutation induces powerful aphrodisiac effects, and Warren and Chrissy have sex before the effects fade and disturbing nightmares begin.

A short time later, Chrissy discovers she is pregnant and spits out a small creature into a nearby toilet. The event marks the start of a dangerous chain reaction in the plant's waste system.

The creature travels through the building's pipes to a barrel filled with radioactive waste and mutates into a larger creature. The mutation foreshadows the deadly threat that will confront the school and the plant's workers.

With the outbreak underway, the plant orders a lockdown and launches an investigation into Dewey’s death. A nuclear plant worker carefully checks the basement, finding no obvious spill but noting a foul odor. After dismissing a sound he had heard before, he looks again and the monster's arm reaches out, claws his face, and kills him.

Overwhelmed by the Cretins' harassment, Warren goes on a radiation-fueled rampage within the school, killing two of the gang. He has no memory of the killings when he later regains consciousness.

The Cretins stage a violent assault inside Tromaville High, overpowering the principal and forcing him to trigger the school’s Radiation Alarm to evacuate. They close the doors, barricade the building, and occupy it, during which they shoot and kill the principal's secretary who opened the door.

They capture Chrissy as bait for Warren and hold her hostage in the basement, planning to kill her in front of him. Their plan is halted when the adult monster arrives.

Warren sneaks into the school to rescue Chrissy and encounters the adult monster. The creature kills the Cretins, and Warren then uses a laser from the physics laboratory to kill the monster, allowing them to flee the building.

Mr. Paley arrives in the room just as the final creature is killed and the school explodes, taking him with it. The surviving students celebrate as the loudspeakers announce that Tromaville High will be shut down for remodeling.

During the remodeling, a new, small creature appears, squirming through the remains of the destroyed school. Its appearance hints that the toxic legacy continues even as rebuilding begins.