Cheech & Chong’s Animated Movie!

The film opens with an interview featuring a crab louse named Buster living on a bikini-clad woman. The body crab spots Man passing by, jumps onto his beard, and is quickly pulled off and discarded.

Pedro De Pacas stops to give Man a ride after spotting him on the street. Man gets in and they peel off, sending the body crab flying as they start their journey.

The body crab smells the marijuana scent and begins to chase them through traffic. They smoke a joint as a police car tailed them looms behind. To avoid arrest, Man eats all the drugs in the car, and the police car passes by.

The body crab, still searching for them, is hit by a train. The bizarre accident ends the chase and leaves chaos behind.

Pedro and Man park near a theater and hear knocking from inside their trunk. They move the car to avoid discovery, but the key breaks off in the lock. Man searches for a crowbar while Pedro exits to urinate on the trunk, revealing two frightened people inside.

A skit with two dogs appears, and the body crab is found in dog excrement and stepped on by Pedro. He carries the crab home on the bottom of his shoe and they watch television, turning channels to various skits.

The TV shows on screen spoof interrogation, a drug-themed game show, a zit treatment commercial, and a Bandstand parody. They pull out a gigantic rolled joint stuffed with a sock and try to smoke it, but it only makes them cough.

The body crab appears at the window of a doctor examining patients. A Jewish family skit features a doctor removing a bullet from a child's nose, which explodes and sends the crab flying. The scene then zooms in on Acapulco Gold as a marijuana joint product is filmed.

Back at Pedro's door, someone pretends to be the police, and Pedro scrambles to dispose of all his drugs. When he finishes, Man appears and quips 'April Fools'.

A newspaper article about Afghanistan leads into a skit set there. The body crab appears on someone's shoulder in Afghanistan but is shot.

The camera shifts to a courtroom skit where Man is on trial. He rambles, collects drugs as evidence, climbs the judge's desk, and eventually passes out, revealing it was a dream.

Pedro knocks on the door to wake Man, and the 'Dave's Not Here' skit unfolds. The body crab, hidden under a deck board, is roasted by sunlight as it briefly turns into a vampire, while Man remains inside and starts watching Wake Up America, a Geraldo Rivera–style expose.

The Wake Up America segment features a journalist and the body crab still pursuing Pedro, landing on an electric wire after a failed dive. The scene then shifts to Man on the phone at a diner, making a drug deal, signaling the tangled chaos continues off screen.