Burt Gummer, now a star in his own survivalist web-series, teams up with his new cameraman, Travis Welker, when two South African Wildlife Ministry agents—Erick Van Wyk and Johan Dreyer—hire them to tackle the Ass-Blasters terrorizing the region. They fly to the remote location, and Burt quickly bonds with their pilot, Den Bravers. When Burt's heavy weaponry is impounded due to local gun laws, Erick provides a small collection of guns he has gathered—though Burt protests that their calibre is far too small to kill the monsters.
The team sets up their quarters at an animal refuge, where Travis befriends a little girl, Amahle Montabu(/actor/nolitha-zulu), and soon develops feelings for Nandi Montabu, the girl’s mother. This sparks a rivalry with a local named Baruti, who is also in love with Nandi. Two paleontologists celebrate after finding fossilized Graboid remains at a dig, but they are attacked and eaten. Investigating the scene, Burt realizes the fossil belongs to a different breed of Graboid. While Travis attends a tribal dance with Nandi, a refuge worker named Thaba is attacked by an Ass-Blaster and carried off. Burt orders the refuge evacuated, then heads out with Erick and Dreyer. They locate the Ass-Blaster in a cave, and Burt kills the flying monster, which kills Dreyer when it falls from the sky. When Burt discovers that the Ass-Blasters have been laying Graboid eggs, Erick reveals himself to be a poacher, planning to sell the eggs on the black market. He locks Burt in a metal cage and leaves with the eggs.
Travis finds Burt the next day, but their truck breaks down and they press on back to the refuge on foot. In the desert, they discover Erick’s truck crashed, with Erick fleeing from a massive Graboid with detachable tentacles, which Burt dubs “The Queen Bitch.” Burt shoots the tentacles, but the Queen Bitch consumes Erick. Burt agrees to let Travis return to the cave to destroy the nest with a grenade, while he contacts the pilot for transport. In the cave, Travis kills an Ass-Blaster with the grenade, but fails to destroy the nest. When Den arrives, Burt uses the helicopter’s rockets to destroy the nest.
Den flies them back to their truck and helps repair the damage. Driving back to the refuge, Travis reveals to Burt that he is his son, the child of a one-night stand in Florida 40 years earlier; hearing of Burt’s exploits, Travis had hoped to follow in his father’s footsteps. At the refuge, the workers are attacked by Ass-Blasters. Nandi, Amahle, and Baruti manage to kill several Ass-Blasters and a Graboid. They head for the village, where they discover that Amahle is hiding a Graboid egg, which explains the attacks. The trio is attacked again, and during the confusion, Amahle wanders away with the egg. Burt and Travis arrive to find the village under siege by the Queen Bitch’s tentacles. Travis retrieves the egg, and Baruti ensures Amahle’s safety.
When the Queen Bitch arrives, Nandi suggests using the daily thunderstorm to kill it. Travis distracts it as the villagers construct a trap. When the storm erupts, Nandi lures the Queen Bitch in with the egg; lightning, drawn to the metal trap, destroys the egg and the Queen Bitch Graboid. Afterwards, Burt accepts Travis as his son, inviting him to join the work. A mid-credits scene shows Burt and Travis now co-hosting Burt’s reality show, traveling the globe to confront a new wave of monsters.
