In 1999, in the vibrant city of London, a tragic incident unfolds as a young Zoya (Katrina Kaif) witnesses the harrowing death of her father, Rehan Nazar (Aamir Bashir), an ISI agent, who loses his life in a devastating bomb blast. Rehan had instilled in Zoya a crucial lesson: a person who kills without justification is a terrorist, not a soldier. His untimely demise is depicted as a consequence of shifting political tides, particularly following Musharraf's ascent to power, which led to the ousting of Nawaz Sharif from the premiership of Pakistan.
Following the funeral, Zoya meets Aatish Rehman (Emraan Hashmi), Rehan's former protege, who persuades her to join the ISI, igniting a path of vengeance as Zoya becomes convinced that India played a role in her father’s death.
In the present, the narrative shifts to Avinash "Tiger" Singh Rathore (Salman Khan), who receives a critical mission briefing from the new RAW chief, Maithili Menon (Revathi). He is tasked with the recovery of his former handler, Gopi Arya (Ranvir Shorey), taken captive in Afghanistan while trying to uncover Taliban plans related to operations targeting Pakistan.
After a daring rescue, Gopi reveals to Tiger that Zoya is intricately involved in a dangerous scheme, indicating her role as a double agent working under the guise of RAW while secretly aligned with ISI. Zoya, now residing in Austria with her son, Junior, is under surveillance as Tiger is assigned to protect another RAW agent, Jibran Sheikh (Neeraj Purohit), who holds crucial information about a militant group’s impending threat.
As tensions rise, Zoya warns Tiger that Nasreen Irani (Simran), the Pakistani Prime Minister, risks her life by proposing significant defense budget cuts, a maneuver that poses immense danger in a country where the Army dictates political power.
When Zoya attempts to assassinate Sheikh, Tiger intervenes, only to be captured by Aatish, who has sinister motivations. The flashbacks reveal Aatish's longstanding ambition to derail peace efforts between India and Pakistan, often resorting to extreme measures.
As Aatish endeavors to leverage Junior’s life for compliance from Tiger and Zoya, they find themselves forced to collaborate with their old allies, including Rakesh (Kumud Mishra), Karan (Anant Vidhaat Sharma), and Nikhil (Chandrachoor Rai), to retrieve a briefcase containing missile launch codes in Istanbul.
The duo’s elaborate ruse turns disastrous when Aatish manipulates the situation, leading to Tiger's arrest in Pakistan where he faces accusations from both ISI and RAW. Meanwhile, Zoya is pursued as a traitor, and both are ensnared in a web of deceit that threatens their lives and the safety of nations.
As the narrative crescendos, Tiger orchestrates a dramatic escape, reuniting with his adopted son, Hassan (Vishal Jethwa), amidst conspiracies to destabilize the leadership of Prime Minister Irani.
Together with their RAW allies and Zoya’s maneuvering, they infiltrate the heart of Pakistani government to thwart the assassination plot against Irani. The stakes become increasingly lethal as betrayals surface, most notably when Aatish's plan to eliminate Irani is revealed, although he uses his accomplice, Javed (Danish Bhatt), to further his agenda.
As the thrilling confrontation reaches its zenith, with lives lost on both sides, Zoya seeks vengeance against Javed, while Tiger battles Aatish to protect their future and safeguard Irani's life. Ultimately, Irani reveals Aatish's treachery to the world, clearing Tiger and Zoya’s names, and establishing their commitment to their respective nations.
In a gripping mid-credits scene, Colonel Sunil Luthra (Ashutosh Rana) reaches out to Kabir Dhaliwal (Hrithik Roshan), hinting at another looming threat that demands justice.
