The film opens with a series of images depicting a man squeezing lemons into a glass. This man is Burke Ryan, the author of the self-help book A-Okay, which aims to help people cope with the grief of losing loved ones. While preparing his drink, Burke, played by Aaron Eckhart, recites the first chapter of his book: Chapter One: If life gives you lemons, make lemonade. However, he adds a twist by mixing in vodka.
As the story unfolds, we see Burke's chaotic day as he heads to the airport in Seattle. His journey is marred by a traffic jam, missing luggage, and unexpected rain, all experienced while dressed in a suit. Upon arriving at his hotel, we are introduced to his manager, Lane (Dane Fogler), who has everything ready for Burke's seminar. Notably, Burke has a phobia of elevators, opting instead to climb the stairs to his room on one of the upper floors.
Once inside his room, Burke changes out of his soaked clothes and takes a moment to calm his nerves with more vodka. As he exits, he collides with Eloise, played by Jennifer Aniston, who is busily arranging flowers in the hotel lobby. Although she seems startled, it quickly becomes clear that she is just preoccupied with her work, rushing away without saying a word. Burke, intrigued, notices a painting that is not aligned properly, leading him to discover that Eloise has written the word "QUIDNUNC" on the wall—an interesting choice referring to a busybody or gossip. This prompts him to search for the definition in a nearby dictionary.
Next, we witness Burke's photo shoot on the hotel's rooftop, where he is grilled about the inspiration behind his book. We learn that it was partly written as a way for Burke to deal with his grief following the tragic loss of his wife in a car accident three years ago. As the photo shoot progresses, the lingering sorrow is evident in Burke’s demeanor.
The seminar kicks off with Burke nervously addressing a sizable audience. To break the ice, he shares a poignant tale about a football coach who overcame immense obstacles only to end his life on the night of a championship—illustrating the depths of grief and the reality that healing cannot be achieved through superficial means alone. Throughout the week, Burke's seminar is filled with various activities and group sessions aimed at helping attendees navigate their own traumas.
In one of the first exercises, Burke takes his group out to the streets, prompting them to voice their observations amidst the chaos of honking vehicles and shouts from passersby. He later brings them to the hotel rooftop, highlighting how changing their perspective can significantly alter their experience of the same location—an important lesson in their healing journey.
Afterward, Burke meets with Lane for a drink where he notices Eloise arranging flowers once again. Determined to connect with her, he approaches, but she silently indicates that she cannot speak. As she leaves the hotel, Burke is left feeling puzzled and disheartened.
In another scene, Burke learns of Walter, a man who is reluctant to participate in the seminar due to the death of his own son. After a heartfelt conversation, Burke convinces Walter to stay, illustrating the community of shared grief that the seminar facilitates. Meanwhile, Eloise discovers her boyfriend's infidelity, leading her to have a heated conversation with her employee, Marty, at her flower shop, revealing her own struggles with love and betrayal.
As Burke navigates his relationship with his father-in-law, who chastises him for continuing to thrive after the loss of his wife, Burke's emotional turmoil becomes palpable. A confrontation with Eloise reveals deep-seated issues and fears, and Burke’s challenges come to a head during a seminar activity where participants attempt to walk across hot coals. When Walter backs out, Burke's own unresolved grief surfaces, and he suffers physical burns in his attempt to encourage him.
Burke's journey continues as he seeks solace in his friendship with Eloise, which blooms despite the personal battles they both face. A series of intimate moments between them leads to a significant realization for Burke about his inability to move on from his wife's death, and the emotional confrontation draws them closer but highlights the obstacles they must overcome.
The climax occurs during the final seminar day, where Burke stands in front of the audience under the watchful eyes of corporate executives. He sheds tears as he admits his failure to heal, branding himself as a hypocrite for preaching recovery while still wrestling with his own grief. When his father-in-law confronts him, their emotional reconciliation resonates with the audience.
In the film's closing moments, Burke seeks out Eloise once more, transformed by his journey. He acknowledges his past while expressing a desire to move forward, leading to a heartfelt embrace and the promise of a new beginning. Meanwhile, Burke's father-in-law finds solace in the return of their parrot, symbolizing healing and acceptance.
The journey through loss, growth, and the importance of genuine connection shapes the essence of this poignant story about confronting grief and the path to recovery.
